Fig. 1 · Structure
Documents & Downloads
Propargyl-PEG4-5-nitrophenyl carbonate
PROTAC Linker
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its alkyne functionality allows for participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing molecules. This compound supports various applications in targeted protein degradation research, enabling the development of innovative therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1422540-81-5 |
| Applications | PROTAC Linker |
| Formula | C18H23NO9 |
| Molecular Weight | 397.38 |
| SMILES | C#CCOCCOCCOCCOCCOC(OC1=CC=C([N+]([O-])=O)C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.