Fig. 1 · Structure
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Bis-PEG4-sulfonic acid
PROTAC Linker
Bis-PEG4-sulfonic acid is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the conjugation of target proteins with E3 ligases, enhancing the recruitment and degradation of specific proteins in cellular systems. This compound is instrumental in developing novel therapeutic strategies for targeted protein degradation in cancer and other diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1807539-08-7 |
| Applications | PROTAC Linker |
| Formula | C10H22O10S2 |
| Molecular Weight | 366.41 |
| SMILES | O=S(CCOCCOCCOCCOCCS(=O)(O)=O)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.