Catalog No.
Product Name
Application
Product Information
Citations
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Serotonin Re-uptake Inhibitor
(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine, acting as a potent serotonin reuptake inhibitor, with a Ki of 13 nM. This compound is primarily utilized in research focusing on the pathophysiology and treatment of depression. Its selective inhibition of serotonin reuptake makes it an essential tool for studying serotonergic signaling and therapeutic interventions in mood disorders. -
Serotonin Reuptake Inhibitor
Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that is orally active. It has been primarily investigated for its biological activity in the treatment of premature ejaculation (PE). Dapoxetine's mechanism of action enhances serotonergic signaling, contributing to increased ejaculatory control and prolonged intravaginal ejaculatory latency. This makes Dapoxetine a valuable reagent in sexual health research and studies focused on sexual dysfunction. -
Serotonin Antagonist
Nor Mianserin Hydrochloride is a serotonin antagonist, acting primarily on serotonin receptors to modulate serotonergic signaling. This compound is utilized in research focused on disorders linked to serotonin metabolism, as well as conditions associated with histamine metabolism. Its pharmacological profile makes it a valuable tool for studying various neuropsychiatric and metabolic diseases. -
MDR Reversal Agent
Tampramine is a phenothiazine derivative that functions as a multidrug resistance (MDR) reversal agent. It demonstrates significant biological activity with effective doses (ED50) of 60 μM in both P388 and P388/ADR cell lines. Tampramine is primarily used in research to explore mechanisms of drug resistance and to enhance the efficacy of chemotherapeutic agents. -
SERT-nnos interaction Promoter
Sakura-6 is a SERT-nNOS interaction promoter that enhances the formation of the SERT-nNOS complex while concurrently decreasing the surface expression of SERT. Experimental administration of Sakura-6 into the dorsal raphe nucleus (DRN) results in the induction of depression-like behaviors in murine models. This compound is valuable for investigating the neurobiological mechanisms of serotonin transport and its implications in mood disorders. -
Norepinephrine Reuptake Inhibitor
Tametraline is a norepinephrine reuptake inhibitor that modulates the levels of norepinephrine in the synaptic cleft. This compound exhibits significant antidepressant activity and is primarily utilized in research investigating neurological disorders, particularly depression. Its mechanism of action may provide insights into the treatment and understanding of mood-related pathologies. -
SerT Inhibitor
SERT-IN-3 is a potent inhibitor of the serotonin transporter (SerT), displaying an IC50 value of 34.4 nM in pharmacological assays. This compound plays a critical role in research applications focused on serotonin modulation, making it a valuable tool for studying neuropharmacology and potential therapeutic interventions in mood and anxiety disorders. -
Serotonin Transporter Inhibitor
(±)-Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor targeting the serotonin transporter. This compound exhibits significant analgesic and antidepressant properties, making it valuable in studies related to diabetic neuropathic pain, fibromyalgia, and major depressive disorder. Researchers utilize (±)-Duloxetine hydrochloride to explore its potential therapeutic effects and underlying mechanisms in various neuropathic and mood disorders. -
Serotonin Transporter Inhibitor
(S)-Venlafaxine is a potent serotonin transporter inhibitor that also affects norepinephrine reuptake. This compound is recognized for its antidepressant properties and is utilized in research to investigate mechanisms of mood disorders and neuropharmacology. Its dual inhibitory action on 5-HT and NE transporters makes it a valuable tool for studying depression and anxiety-related pathways. -
Fenfluramine Metabolite
Norfenfluramine is a major brain-penetrant metabolite of Fenfluramine that primarily interacts with 5-HT transporters, facilitating the release of serotonin from neurons. This compound has been observed to exhibit antiepileptic effects in vivo, making it relevant for research in neuropharmacology and the study of serotonin-related disorders. Its efficacy in modulating serotonin levels could provide insights into therapeutic strategies for epilepsy and other neurological conditions. -
Serotonin Transporter
MADAM is a highly selective compound that targets the serotonin transporter (5-HTT) with a Ki value of 1.6 nM. This compound has significant potential as a PET radiotracer, allowing for the visualization of the serotonin transporter in various research applications. Its high affinity for 5-HTT makes it a valuable tool for studying serotonin-related pathways and conditions. -
Dual Serotonin and Noradrenaline Monoamine reuptake Inhibitor
SNRI-IN-1 is a dual serotonin and noradrenaline monoamine reuptake inhibitor that demonstrates significant activity in modulating neurotransmitter levels. With a P-glycoprotein Efflux Ratio of 20, this compound is useful in studying the dynamics of monoamine transport and its implications in mood disorders and cognitive function. Research applications include investigating the effects of dual inhibition on neurotransmission and potential therapeutic benefits in conditions such as depression and anxiety. -
Guaiane-type Compound
Nardoguaianone J is a guaiane-type compound isolated from the roots of Nardostachys chinensis. This compound is known to enhance serotonin transporter (SERT) activity, making it relevant in studies related to serotonin signaling and neurotransmission. Nardoguaianone J is valuable for research into mood regulation, depression, and related neurological disorders. -
Serotonin-norepinephrine Reuptake Inhibitor
Duloxetine-d3 hydrochloride is a deuterium-labeled derivative of Duloxetine hydrochloride, functioning as a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM. This compound is primarily utilized in research to study the pharmacokinetics and biological effects of Duloxetine in models of major depressive disorder and generalized anxiety disorder. Its stable isotope labeling enables precise tracking in metabolic studies and enhances the understanding of drug metabolism and action mechanisms. -
5-hydroxytryptamine Uptake Inhibitor
Serotonin azidobenzamidine is a selective inhibitor of 5-hydroxytryptamine (serotonin) uptake, functioning through competitive inhibition. It demonstrates significant biological activity with a Ki value of 130 nM, effectively inhibiting [3H]5-hydroxytryptamine uptake in rat cortical synaptosomes. This reagent is valuable in neuropharmacological research, aiding in the study of serotonin modulation and its effects on various physiological processes. -
Venlafaxine Active Metabolite
Desvenlafaxine succinate is the succinate salt form of the primary active metabolite of Venlafaxine, serving as a selective inhibitor of serotonin and norepinephrine reuptake. It exhibits IC50 values of 47.3 nM for the human serotonin transporter (hSERT) and 531.3 nM for the human norepinephrine transporter (hNET), offering significant potential in modulating neurotransmitter levels. Additionally, Desvenlafaxine succinate demonstrates modest binding affinity at the human dopamine transporter, with 62% inhibition observed at a concentration of 100 μM. This compound is valuable for research in neuropsychiatric conditions and the study of antidepressant mechanisms. -
Serotonin Transporter Control
(1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride primarily targets the serotonin transporter, influencing serotonin reuptake mechanisms. This compound serves as a metabolite of the selective serotonin reuptake inhibitor Sertraline, facilitating investigations into its pharmacodynamics and pharmacokinetics. Its relevance in researching mood disorders and antidepressant effects makes it a valuable tool for studies focused on serotonin modulation. -
Serotonin Transporter Inhibitor
(S)-Tomoxetine hydrochloride is a selective serotonin transporter inhibitor known for its ability to modulate serotonin levels in synaptic clefts. With a reported inhibition constant (Ki) of 16.8 nM, it effectively inhibits the reuptake of norepinephrine, thereby influencing neurotransmitter dynamics. This compound is utilized in research focused on neuropharmacology, mood disorders, and the mechanisms of serotonin signaling. -
Fluoxetine Derivative
Norfluoxetine oxalate is an active metabolite of Fluoxetine, functioning primarily as a selective serotonin reuptake inhibitor (SSRI). This compound exhibits significant antidepressant activity, making it a valuable tool in psychiatric research. It is commonly utilized to study the mechanisms of depression and the efficacy of SSRI treatments. -
Antidepressant
(1S,4S)-N-Desmethyl Sertraline hydrochloride is a metabolite of Sertraline, acting primarily as a selective serotonin reuptake inhibitor. This compound exhibits significant antidepressant activity, making it valuable in the study of depression and related disorders. It is utilized in research to investigate serotonin modulation and its effects on mood and behavior. -
Serotonin Reuptake Inhibitor
(S)-Norfluoxetine is a selective serotonin reuptake inhibitor that primarily targets the serotonin transporter. It has been shown to enhance allopregnanolone levels and decrease aggressive behavior in socially isolated murine models. This compound is valuable in research related to neuropharmacology and the understanding of mood and anxiety disorders. -
Nervous System Stimulant
3-Chloroamphetamine hydrochloride is a derivative of amphetamine that acts as a central nervous system stimulant primarily by promoting the release of serotonin and dopamine. This compound exhibits notable effects on mood enhancement and increased energy levels, making it valuable for research into neuropharmacology and the study of stimulant effects on behavior. Its ability to modulate neurotransmitter activity positions it as a useful tool in investigating conditions related to mood disorders and attention. -
SERT Inhibitor
Nardosinonediol is a selective serotonin transporter (SERT) inhibitor. It demonstrates significant modulation of serotonin uptake, making it a valuable tool for studying serotonin-related pathways. This compound is primarily used in research focused on neuropharmacology, mood disorders, and the development of antidepressant therapies. -
Serotonin Reuptake Inhibitor
(Rac)-Dapoxetine hydrochloride is a racemic mixture of Dapoxetine hydrochloride, a selective serotonin reuptake inhibitor (SSRI) that primarily targets serotonin transporters. This compound exhibits notable efficacy in the treatment of premature ejaculation (PE) and is valuable in research aimed at understanding this condition. Its pharmacological profile positions it as a significant tool for studying serotonin-related pathways in human sexual health. -
Serotonin Transporter Control
N-Nitroso fluoxetine is a derivative of fluoxetine that acts as a selective serotonin reuptake inhibitor (SSRI). This compound primarily targets the serotonin transporter, modulating serotonin levels in the synaptic cleft and influencing mood regulation. N-Nitroso fluoxetine is utilized in antidepressant research, contributing to the understanding of serotonin modulation in psychiatric disorders. -
Serotonin Reuptake Inhibitor
DA-8031 is a selective serotonin reuptake inhibitor (SSRI) with oral bioavailability. It demonstrates the ability to modulate serotonin levels, making it a valuable compound for studying conditions related to serotonin dysregulation, particularly premature ejaculation (PE). This compound serves as an important tool for research into therapeutic interventions for PE and related disorders. -
Serotonin Reuptake Inhibitor
Lubazodone is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter. It exhibits significant antidepressant activity and is utilized in the investigation of various depressive disorders. Research applications include exploring its effects on mood regulation and neurochemical pathways associated with depression. -
Endogenous Metabolite
D-myo-Inositol-1,4,5,6-tetraphosphate (D-Ins(1,4,5,6)P4) functions primarily as an endogenous metabolite involved in cellular signaling pathways. This compound exhibits a strong inhibitory effect on calcium-activated chloride channels, effectively operating at concentrations of 8-10 μM. It is commonly utilized in research applications focused on signal transduction and ion channel regulation. -
Biochemical Reagent
D-myo-Inositol-4,5-diphosphate sodium is a critical biochemical reagent that functions as a second messenger in cellular signaling pathways. It primarily targets calcium channels, facilitating the release of intracellular calcium when it binds to its receptor on the endoplasmic reticulum. This compound is valuable for research applications investigating signal transduction, calcium homeostasis, and cellular responses in various biological systems. -
Endogenous Metabolite
Stearoyl serotonin is a hybrid compound designed to target the endogenous metabolite systems and is structurally derived from arachidonoyl serotonin. This compound is investigated for its ability to function as a dual antagonist of fatty acid amide hydrolase (FAAH) and the TRPV1 channel, which are critical pathways in the modulation of pain. Preliminary studies suggest that modifications to the arachidonoyl structure, such as the introduction of an 18-carbon stearoyl moiety, may influence TRPV1 channel activity; replacement with saturated fatty acids has demonstrated significant inhibition of capsaicin-induced activation. This positions stearoyl serotonin as a potential candidate for research into pain mechanisms and therapeutic applications. -
Endogenous Metabolite
SU200 is a TRPV1 agonist that modulates intracellular calcium ion concentrations. It induces distinct calcium ion response patterns, displaying notable reactivity and peak efficacy. The effects of SU200 exhibit varying degrees of response delay and variability across different cell types. This compound offers potential avenues for pharmacological development and further research into calcium signaling pathways. -
Stable Isotope
rac Felodipine-(Methoxy-d3) is a deuterium-labeled analog of rac Felodipine, a potent calcium channel blocker that primarily targets L-type calcium channels. This stable isotope variant is useful for pharmacokinetic studies, metabolic tracing, and isotopic labeling in drug development research. Its deuterium labeling enhances the analytical sensitivity and specificity in mass spectrometry applications, facilitating the investigation of drug absorption, distribution, metabolism, and excretion (ADME) profiles. -
Stable Isotope
Zonisamide-13C2,15N is a deuterated derivative of Zonisamide, designed to serve as a stable isotope for various research applications. Its primary mechanism targets multiple neuronal pathways, primarily focusing on inhibiting voltage-gated sodium channels and modulating neurotransmitter release. This stable isotope variant is invaluable in pharmacokinetic studies, metabolic labeling, and tracer applications, enabling enhanced tracking of Zonisamide in biological systems. -
Isotope-Labeled Compound
Dibucaine-d9 is a deuterium-labeled derivative of dibucaine, a potent sodium channel inhibitor. It serves as a selective inhibitor of pseudocholinesterase (SChE), making it valuable for studying cholinergic signaling. This isotope-labeled compound is particularly useful in pharmacokinetic studies and metabolic profiling, providing insights into drug metabolism and safety evaluation in chemical research. -
Stable Isotope
Atomoxetine-d5 is a deuterium-labeled derivative of Atomoxetine, a selective norepinephrine reuptake inhibitor that demonstrates Ki values of 5, 77, and 1451 nM for norepinephrine (NE), serotonin (5-HT), and dopamine (DA) transporters, respectively. This compound enhances catecholaminergic neurotransmission and increases DAEX and NEEX levels in the prefrontal cortex (PFC). Atomoxetine-d5 is valuable for research applications related to attention-deficit hyperactivity disorder (ADHD) and the study of sodium channel (VGSC) modulation. -
Stable Isotope
cis-Dihydro Tetrabenazine-d7 is a deuterium-labeled analog of cis-Dihydro Tetrabenazine, primarily utilized as a stable isotope in research applications. Its incorporation of deuterium enhances the precision of metabolic studies and pharmacokinetic analyses. This reagent is valuable in the investigation of vesicular monoamine transporters and can aid in the understanding of neurological disorders where dopaminergic signaling is implicated. -
Cypermethrin Isomer
(1R,2S,1'R)-Cypermethrin is a specific isomer of the pyrethroid pesticide Cypermethrin, classified as Class II due to its moderate toxicity. This compound exhibits significant neurotoxic activity by interacting with voltage-gated sodium channels, leading to prolonged neuronal depolarization. (1R,2S,1'R)-Cypermethrin is primarily employed in research focusing on its effects on nervous system function and insecticidal action. Its ability to cross the blood-brain barrier allows for studies on its impact on both invertebrate and vertebrate models. -
Isotope-Labeled Compounds
Cilnidipine-d3 is a deuterium-labeled derivative of Cilnidipine, primarily acting as a calcium channel blocker. This isotope-labeled compound is valuable for research applications involving pharmacokinetic studies and metabolic profiling. Its use enhances the understanding of Cilnidipine's pharmacological effects and its interactions within biological systems. -
Stable Isotope
Pantoprazole-d4 is a deuterated derivative of Pantoprazole, a potent proton pump inhibitor that targets the H+/K+-ATPase enzyme with an IC50 of 6.8 μM. This stable isotope is utilized primarily in pharmacokinetic studies and metabolic research to enhance the accuracy of drug absorption and distribution analysis. Pantoprazole exhibits anti-secretory and anti-ulcer properties, while its combination with Doxorubicin has been shown to significantly increase tumor growth delay, underscoring its potential utility in cancer research. -
Stable Isotope
Cinnarizine-d8 dihydrochloride is a deuterium-labeled form of the calcium channel blocker Cinnarizine. This stable isotope compound allows for precise tracking and analysis in pharmacokinetic studies. It is primarily utilized in research applications involving metabolic studies and the investigation of drug interactions, enhancing the understanding of pharmacological mechanisms. -
Isotope-Labeled Compounds
Digitoxin-d3 is a deuterated derivative of digitoxin, a cardiac glycoside that primarily targets the Na+/K+ ATPase enzyme, enhancing intracellular calcium levels and improving myocardial contractility. This isotope-labeled compound is utilized in pharmacokinetic studies, providing insights into the metabolism and distribution of digitoxin in biological systems. It serves as a valuable tool for researchers examining heart function and the therapeutic mechanisms of cardiac glycosides. -
Reserpine Analog
Bishomoreserpine is a reserpine analog that acts primarily as a monoamine transporter inhibitor. It exhibits significant inhibitory activity, impacting neurotransmitter uptake and revealing potential roles in studying neuropharmacology. This compound is useful in research aimed at understanding the mechanisms of neurotransmitter regulation and developing therapeutic strategies for related disorders. -
Calcium Channel Blocker
Verapamil-d6 hydrochloride is a deuterated derivative of Verapamil, a selective calcium channel blocker. It exhibits potent inhibition of P-glycoprotein (P-gp) and CYP3A4, making it valuable in cardiovascular research, particularly for conditions such as hypertension, arrhythmias, and angina. This isotopically labeled compound aids in pharmacokinetic studies and offers insights into drug metabolism and transport mechanisms. -
Stable Isotope
N-Desalkylflurazepam-d4 is a deuterated analog of N-Desalkylflurazepam, a long-acting metabolite of benzodiazepine compounds, including Flurazepam. This stable isotope is primarily used for research applications involving metabolic studies and pharmacokinetics of benzodiazepines. N-Desalkylflurazepam exhibits inhibitory effects on L-type voltage-gated calcium channels, with reported IC50 values of 55 μM for Cav1.2 and 37 μM for Cav1.3, making it a valuable tool for investigating calcium channel modulation in various biological contexts. -
Stable Isotope
Nifedipine dehydro nitroso-d6 is a deuterium-labeled derivative of Nifedipine dehydro nitroso, primarily utilized as a stable isotope. This compound plays a crucial role in the study of pharmacokinetics and metabolic pathways of calcium channel blockers. Its isotopic labeling facilitates advanced analytical techniques such as mass spectrometry in chemical research applications. -
Stable Isotope
Cyhalothrin-d5 is a deuterated version of Cyhalothrin, a synthetic pyrethroid insecticide that primarily targets voltage-gated sodium channels in insect nerves. This stable isotope is essential for chemical research and environmental studies, particularly in trace analysis and bioaccumulation studies of pesticides. Cyhalothrin-d5 allows for precise quantification in analytical applications, enhancing the understanding of pest management and its ecological impacts. -
Stable Isotope
Desacetyl Diltiazem-d3 is a deuterium-labeled derivative of Desacetyl Diltiazem, designed to serve as a stable isotope standard in analytical applications. This compound can be employed in pharmacokinetic studies and metabolic labeling to trace drug interactions and bioavailability. Its precise labeling enhances accuracy in mass spectrometry and other analytical techniques, making it an invaluable tool for researchers investigating calcium channel blocking activities and cardiovascular-related pharmacology. -
Stable Isotope
2-[(2-Azidoethoxy-d4)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine is a deuterium-labeled compound that targets dihydropyridine receptors. This stable isotope variant is significant in researching the pharmacokinetics and metabolic pathways of dihydropyridine derivatives. It is particularly valuable in studies involving the pharmacological effects and interactions of calcium channel blockers, facilitating advanced analysis in medicinal chemistry and drug development. -
Pregabalin Impurity
Pregabalin lactam is an impurity of Pregabalin, a compound primarily targeting calcium channels. This metabolite is often utilized in quality control and analytical studies of Pregabalin formulations. Its presence in research can provide insights into compound stability and purity, contributing to a better understanding of Pregabalin's pharmacological profile. -
Drug Impurity
Flecainide Impurity 3 is a known impurity of the antiarrhythmic agent Flecainide, which primarily targets sodium channels to exert its pharmacological effects. This compound is crucial for quality control in the pharmaceutical industry, allowing researchers to assess the purity and stability of Flecainide formulations. Its identification and quantification are essential for ensuring compliance with regulatory standards in drug development and manufacturing.
