BPAM363 is an orally active, selective positive allosteric modulator (PAM) of AMPA receptors (AMPARs). It effectively enhances AMPAR activity in both human and rat models, exhibiting an EC2x value of 0.96 μM in rat embryonic cortical primary neurons. Additionally, BPAM363 promotes the upregulation of brain-derived neurotrophic factor (BDNF) protein expression in rat primary cortical neuronal cultures and increases AMPA-mediated excitatory postsynaptic responses in rat and mouse models. This compound is valuable for researching cognitive disorders and related neurological conditions.
BPAM363 is an orally active, selective positive allosteric modulator (PAM) of AMPA receptors (AMPARs). It effectively enhances AMPAR activity in both human and rat models, exhibiting an EC2x value of 0.96 μM in rat embryonic cortical primary neurons. Additionally, BPAM363 promotes the upregulation of brain-derived neurotrophic factor (BDNF) protein expression in rat primary cortical neuronal cultures and increases AMPA-mediated excitatory postsynaptic responses in rat and mouse models. This compound is valuable for researching cognitive disorders and related neurological conditions.
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