(S)-CPW 399 is a subtype-selective full agonist of AMPA receptors, demonstrating a 20-fold higher affinity for GluA1 and GluA2 subunits compared to GluA3 and GluA4 subunits. By activating AMPA receptors with GluA1 subunits, (S)-CPW 399 significantly enhances the spontaneous firing rate of locus coeruleus noradrenergic neurons. This compound is valuable for research into neurological diseases, providing insights into synaptic transmission and neuronal excitability.
(S)-CPW 399 is a subtype-selective full agonist of AMPA receptors, demonstrating a 20-fold higher affinity for GluA1 and GluA2 subunits compared to GluA3 and GluA4 subunits. By activating AMPA receptors with GluA1 subunits, (S)-CPW 399 significantly enhances the spontaneous firing rate of locus coeruleus noradrenergic neurons. This compound is valuable for research into neurological diseases, providing insights into synaptic transmission and neuronal excitability.
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