OCT

OAC1 enhances iPSC reprogramming efficiency by enhancing Oct4 and Nanog driven gene expression.

O4I1 increases Oct3/4 mRNA levels in HEK293 cells by 2.5- and 4-fold at 10 uM and 20 uM, respectively.

Monocrotaline is a natural 11-membered macrocyclic pyrrolizidine alkaloid used in an animal model of pulmonary hypertension.

OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.

O4I2 is a potent inducers of Oct3/4. O4I2 showed high activity in enforcing Oct3/4 expression. O4I2 is a new class of small molecules suitable for iPSC generation.

Oct3/4-inducer-1 (compound 2) is a potent Oct3/4 inducer. Oct3/4-inducer-1 promotes expression and stabilization of Oct3/4, and enhances its transcriptional activity in diverse human somatic cells.