Fig. 1 · Structure
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GYKI-47261 dihydrochloride
AMPA Receptor Antagonist
GYKI-47261 dihydrochloride is a selective, orally active antagonist of the AMPA receptor, exhibiting an IC50 of 2.5 μM. This compound demonstrates a wide range of anticonvulsive activity and offers neuroprotective effects, making it valuable for neurological research. Additionally, GYKI-47261 serves as a potent inducer of the cytochrome P450 enzyme CYP2E1, further expanding its potential applications in pharmacological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1217049-32-5 |
| Applications | AMPA Receptor Antagonist |
| Formula | C18H17Cl3N4 |
| Molecular Weight | 395.71 |
| SMILES | NC1=CC=C(C2=NN3C(CC4=CC=C(Cl)C=C42)=NC(C)=C3)C=C1.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.