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D15

Catalog No.: A67182
AMPAR Inhibitor.
D15 is an AMPA receptor (AMPAR) endocytosis inhibitor derived from a 15 amino acid segment of dynamin. It inhibits the interaction of dynamin with amphiphysin 1 and 2, leading to a significant increase in AMPAR excitatory postsynaptic potential (EPSC) amplitude in medium spiny neurons (MSNs) within Sapap3 knockout mice. This peptide has valuable applications in the investigation of neuropsychiatric disorders and related signaling pathways.
D15 251939-41-0 AMPAR Inhibitor.
Grouped product items
Size Price Stock Qty
1mg
$45.00
In stock
5mg
$110.00
In stock
10mg
$185.00
In stock
25mg
$335.00
In stock
50mg
$490.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionD15 is an AMPA receptor (AMPAR) endocytosis inhibitor derived from a 15 amino acid segment of dynamin. It inhibits the interaction of dynamin with amphiphysin 1 and 2, leading to a significant increase in AMPAR excitatory postsynaptic potential (EPSC) amplitude in medium spiny neurons (MSNs) within Sapap3 knockout mice. This peptide has valuable applications in the investigation of neuropsychiatric disorders and related signaling pathways.
Product Information
Catalog NumA67182
FormulaC69H111N23O19
Molecular Weight1566.76
CAS Number251939-41-0
SequencePro-Pro-Pro-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-Pro-Gly
Sequence shorteningPPPQVPSRPNRAPPG
SMILESC(=O)([C@H]1N(C(=O)[C@@H]2CCCN2)CCC1)N3[C@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(=O)N5[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N6[C@H](C(=O)N7[C@H](C(NCC(O)=O)=O)CCC7)CCC6)C)=O)CCCNC(=N)N)=O)CC(N)=O)=O)CCC5)CCCNC(=N)N)=O)CO)=O)CCC4)[C@H](C)C)=O)CCC(N)=O)=O)CCC3
SynonymsDynamin II (828–842)
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Membrane Transporters-Ion Channels > AMPA receptor