LY 215490 is a selective, competitive antagonist of the AMPA receptor, exhibiting inhibitory potency with IC50 values of 4.8 μM against AMPA, 26.4 μM against CGS 19755, and 247 μM against kainate. This compound demonstrates neuroprotective effects, particularly in the context of focal ischaemia. LY 215490 serves as a valuable tool in studying excitatory neurotransmission and its implications in neurodegenerative diseases.
LY 215490 is a selective, competitive antagonist of the AMPA receptor, exhibiting inhibitory potency with IC50 values of 4.8 μM against AMPA, 26.4 μM against CGS 19755, and 247 μM against kainate. This compound demonstrates neuroprotective effects, particularly in the context of focal ischaemia. LY 215490 serves as a valuable tool in studying excitatory neurotransmission and its implications in neurodegenerative diseases.
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