YM928 is a noncompetitive antagonist of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. This compound effectively inhibits AMPA receptor-mediated neurotoxicity in primary rat hippocampal cultures with an IC50 of 2 μM. Additionally, YM928 blocks AMPA-induced intracellular calcium influx (IC50 of 3 μM) and antagonizes AMPA-induced inward currents (IC50 of 1 μM). It holds potential for research into various neurological disorders.
YM928 is a noncompetitive antagonist of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. This compound effectively inhibits AMPA receptor-mediated neurotoxicity in primary rat hippocampal cultures with an IC50 of 2 μM. Additionally, YM928 blocks AMPA-induced intracellular calcium influx (IC50 of 3 μM) and antagonizes AMPA-induced inward currents (IC50 of 1 μM). It holds potential for research into various neurological disorders.
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