KRP-199 is a potent antagonist of the α-amino-3-hydroxy-5-methylisoxazolepropionic acid receptor (AMPA-R), exhibiting a Ki of 16 nM. This compound demonstrates high selectivity for AMPA-R, contributing to significant neuroprotective effects in vivo. KRP-199 is useful for investigating mechanisms underlying neurodegenerative diseases and evaluating potential therapeutic approaches.
KRP-199 is a potent antagonist of the α-amino-3-hydroxy-5-methylisoxazolepropionic acid receptor (AMPA-R), exhibiting a Ki of 16 nM. This compound demonstrates high selectivity for AMPA-R, contributing to significant neuroprotective effects in vivo. KRP-199 is useful for investigating mechanisms underlying neurodegenerative diseases and evaluating potential therapeutic approaches.
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