EGIS-8332 is a non-competitive antagonist of the AMPA receptor, effectively inhibiting AMPA-mediated currents in rat cerebellar Purkinje cells. It demonstrates a potent capability to block AMPA- and Quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons, with an IC50 ranging from 5.1 to 9.0 μM. EGIS-8332 exhibits notable anticonvulsant and neuroprotective properties, making it a valuable tool for research in neurological diseases.
EGIS-8332 is a non-competitive antagonist of the AMPA receptor, effectively inhibiting AMPA-mediated currents in rat cerebellar Purkinje cells. It demonstrates a potent capability to block AMPA- and Quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons, with an IC50 ranging from 5.1 to 9.0 μM. EGIS-8332 exhibits notable anticonvulsant and neuroprotective properties, making it a valuable tool for research in neurological diseases.
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