(R)-3,4-DCPG is a selective antagonist of AMPA and NMDA receptors, demonstrating a Kd of 77 μM for AMPA. At a concentration of 500 μM, it fully antagonizes NMDA-induced depolarization, while exhibiting weaker antagonistic effects on kainate-induced depolarizations. This compound is valuable for research exploring synaptic transmission and neuropharmacology, particularly in studies investigating excitotoxicity and related neurological disorders.
(R)-3,4-DCPG is a selective antagonist of AMPA and NMDA receptors, demonstrating a Kd of 77 μM for AMPA. At a concentration of 500 μM, it fully antagonizes NMDA-induced depolarization, while exhibiting weaker antagonistic effects on kainate-induced depolarizations. This compound is valuable for research exploring synaptic transmission and neuropharmacology, particularly in studies investigating excitotoxicity and related neurological disorders.
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