Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Monoamine transporter inhibitors block reuptake of dopamine, noradrenaline and serotonin into neurons or vesicles. Plasma membrane transporters for dopamine (DAT), noradrenaline (NET) and serotonin (SERT) clear released transmitter from the synapse. Mice lacking DAT show hyperlocomotion and no response to cocaine or amphetamine, which identified this transporter as their main target. Vanoxerine 2HCl and GBR 12783 dihydrochloride are selective dopamine uptake inhibitors. Milnacipran hydrochloride inhibits both serotonin and noradrenaline reuptake at the plasma membrane. Vesicular monoamine transporters (VMAT) load monoamines into synaptic vesicles and are inhibited by reserpine. GZ-793A is a more selective inhibitor of the VMAT2 isoform.
Synonyms: GBR-12909
Vanoxerine (GBR-12909) is a piperazine derivative which is a potent and selective DRI.
Reboxetine is an antidepressant compound that selectively inhibits norepinephrine uptake (IC50s = 8.2 and 1,070 nM for norepinephrine and serotonin transporters, respectively). It displays greater than 1,000-fold affinity for binding rat norepinephrine receptors compared to serotonin, histamine, acetylcholine, or dopamine receptors (Kis = 1.1, 129, 1,400, 3,900, and >10,000 nM, respectively).
Synonyms: 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1
Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.
Synonyms: Ro 8-4650
Diclofensine (Ro 8-4650) acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and noradrenaline.
Synonyms: 3',4'; 5,7-Tetrahydroxyflavone; Luteoline; Luteolol
Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property.
Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor.
Synonyms: Serpivite; Serpasil; Serpalan
Reserpine acts as an inhibitor of vesicular monoamine transporter 2 (VMAT2), thereby influencing neurotransmitter storage and release. This compound is widely utilized in research studies focusing on autophagy inhibition and its implications in various neurodegenerative disorders. Additionally, reserpine's effects on monoamine levels make it a valuable tool in the investigation of psychiatric conditions and the biochemical pathways involved in these diseases.
Milnacipran hydrochloride is a potent serotonin and norepinephrine reuptake inhibitor (SNRI) that primarily targets the serotonin transporter and norepinephrine transporter, with Ki values of 8.5 nM and 31 nM, respectively. This compound demonstrates antidepressant, anxiolytic, and analgesic activities, making it valuable for research into major depressive disorder, anxiety disorders, and neuropathic pain conditions such as fibromyalgia. Additionally, Milnacipran hydrochloride has been shown to inhibit pERK1/2 activation and reduce biting behavior in murine models, further supporting its role in behavioral studies.
Synonyms: SPD473
SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior.
Synonyms: GBR12783
GBR 12783 dihydrochloride is a very potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).
GZ-793A is a selective inhibitor of vesicular monoamine transporter 2 (VMAT2), which transports the monoamine neurotransmitters from cellular cytosol into synaptic vesicles.
Synonyms: LY2216684 HCl; LY-2216684
Edivoxetine HCl is a drug which acts as a selective norepinephrine reuptake inhibitor
Synonyms: Phenotropyl; Phenotropil; Carphedon; Fonturacetam; Karfedon
Phenylpiracetam is a phenylated derivative of the nootropic drug piracetam. It is used as a stimulant nootropic drug that can be up to 30-60 times more potent than piracetam.
Out of stock
All 4 sizes
Synonyms: Pristiq succinate hydrate; O-Desmethylvenlafaxine succinate hydrate
Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
Synonyms: NBI-98854; MT-5199
Valbenazine is a potent and selective VMAT2 inhibitor.
Synonyms: O-Desmethylvenlafaxine
Desvenlafaxine is a selective 5-HT and norepinephrine reuptake inhibitor, primarily targeting the serotonin transporter (hSERT) and norepinephrine transporter (hNET) with IC50 values of 47.3 nM and 531.3 nM, respectively. This orally active compound effectively penetrates the blood-brain barrier, making it applicable in the treatment of major depressive disorders. Additionally, Desvenlafaxine exhibits weak binding affinity to the human dopamine transporter, with 62% inhibition observed at 100 μM, which may have implications for its overall pharmacological profile.
Sertraline hydrochloride is a selective serotonin reuptake inhibitor (SSRI) primarily used in the treatment of major depressive disorder and obsessive-compulsive disorder. By enhancing serotonergic activity in the central nervous system, it alleviates symptoms of depression and anxiety. This compound is widely utilized in both clinical research and pharmacological studies aimed at understanding its neurobiological effects and potential applications in various mood disorders.
Synonyms: NBI-98854 tosylate
Valbenazine tosylate is a selective inhibitor of the vesicular monoamine transporter 2 (VMAT2), exhibiting a Ki value in the range of 110-190 nM. It is primarily employed in research related to neuropharmacology and the treatment of movement disorders, such as tardive dyskinesia. By inhibiting VMAT2, Valbenazine tosylate modulates neurotransmitter release, making it a valuable tool for studying dopaminergic signaling and associated pathologies.
Synonyms: Amezinium Metilsulfate; LU-1631; Regulton; Risumic
Amezinium Metilsulfate, also known as Regulton and LU-1631, is a norepinephrine reuptake inhibitor which exclusively affects postganglionic sympathetic neurons. Amezinium Metilsulfate is used to treat hypotension.
Synonyms: Serpivite hydrochloride; Serpasil hydrochloride; Serpalan hydrochloride
Reserpine hydrochloride is a potent inhibitor of the vesicular monoamine transporter 2 (VMAT2). It is primarily utilized in research to study neurotransmitter release and its implications in neurodegenerative diseases and mental health disorders. By inhibiting VMAT2, Reserpine hydrochloride disrupts the storage of monoamines, allowing for investigation into their effects on various physiological and pathological processes.
Synonyms: (+)-DTBZ; (+)-α-Dihydrotetrabenazine; (+)-α-DHTBZ
NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.
Synonyms: GBR 12909; I893
Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM).
GBR 12935 is a potent, and selective dopamine reuptake inhibitor.
Synonyms: Ro 1-9569 Racemate
Tetrabenazine Racemate (Ro 1-9569 Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2).
(R)-Viloxazine Hydrochloride is the R-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) that can be used as an antidepressant.
