A-966492

Name: A-966492
Brand: Adooq Bioscience
SKU: A10019
Rating: 100 (268 reviews)

Catalog No.: A10019

PARP1 inhibitor

A-966492 Chemical Structure

CAS NO. 934162-61-5

A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $90.00 Special Price $72.00
10 mg	Regular Price: $160.00 Special Price $128.00
50 mg	Regular Price: $450.00 Special Price $360.00
100 mg	Regular Price: $750.00 Special Price $600.00
10mM * 1mL in DMSO	Regular Price: $117.00 Special Price $93.60
Custom Size	Get quote

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Biological Activity

A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.

Targets

PARP1	PARP1	PARP2
1 nM(Ki)	1 nM(EC50)	1.5 nM(Ki)

Solubility *

In vitro	DMSO	Warmed: 60 mg/mL (184.98 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.83 mL	154.13 mL	308.26 mL
0.5 mM	6.17 mL	30.83 mL	61.65 mL
1 mM	3.08 mL	15.41 mL	30.83 mL
5 mM	0.62 mL	3.08 mL	6.17 mL

*The above data is based on the productmolecular weight 324.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10019
Actions	Inhibitor
CAS No.	934162-61-5
Formula	C18H17FN4O
M. Wt	324.4
Purity	>98%
Synonyms	A966492
SMILES	C1CC(NC1)C2=CC(=C(C=C2)C3=NC4=C(C=CC=C4N3)C(=O)N)F
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.