Biological Activity
A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.
Targets
PARP1 | PARP1 | PARP2 | ||
1 nM(Ki) | 1 nM(EC50) | 1.5 nM(Ki) |
In vitro | DMSO | Warmed: 60 mg/mL (184.98 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 30.83 mL | 154.13 mL | 308.26 mL |
0.5 mM | 6.17 mL | 30.83 mL | 61.65 mL |
1 mM | 3.08 mL | 15.41 mL | 30.83 mL |
5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
*The above data is based on the productmolecular weight 324.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10019 |
---|---|
Actions | Inhibitor |
CAS No. | 934162-61-5 |
Formula | C18H17FN4O |
M. Wt | 324.4 |
Purity | >98% |
Synonyms | A966492 |
SMILES | C1CC(NC1)C2=CC(=C(C=C2)C3=NC4=C(C=CC=C4N3)C(=O)N)F |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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