E7449

Catalog No.: A21553

PARP1/PARP2 inhibitor

E7449

E7449 Chemical Structure

CAS NO. 1140964-99-3

E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.

Availability: In stock

Package Price Qty
5 mg
$130.00
10 mg
$223.00
50 mg
$662.00
100 mg
$1,325.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.51 mL 157.56 mL 315.12 mL
0.5 mM 6.3 mL 31.51 mL 63.02 mL
1 mM 3.15 mL 15.76 mL 31.51 mL
5 mM 0.63 mL 3.15 mL 6.3 mL

*The above data is based on the productmolecular weight 317.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21553
Actions Inhibitor
M. Wt 317.34
Formula C18H15N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1140964-99-3
Synonyms E-7449, E 7449
SMILES O=C1NNC2=C3C1=CC=CC3=NC(CN4CC5=C(C=CC=C5)C4)=N2

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