Niraparib tosylate

Catalog No.: A16618

PARP1/PARP2 inhibitor

Niraparib tosylate

Niraparib tosylate Chemical Structure

CAS NO. 1038915-73-9

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$63.00
10 mg
$109.00
50 mg
$322.00
100 mg
$644.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Laurie B Schenkel, .et al. A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants, Cell Chem Biol, 2021, Mar 2;S2451-9456(21)00095-7 PMID: 33705687

Biological Activity

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively.
In vitro DMSO 86 mg/mL (174.58 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.3 mL 101.5 mL 203.01 mL
0.5 mM 4.06 mL 20.3 mL 40.6 mL
1 mM 2.03 mL 10.15 mL 20.3 mL
5 mM 0.41 mL 2.03 mL 4.06 mL

*The above data is based on the productmolecular weight 492.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16618
Actions Inhibitor
CAS No. 1038915-73-9
Formula C26H28N4O4S
M. Wt 492.59
Purity >98%
Synonyms MK-4827 tosylate
SMILES NC(C1=CC=CC2=CN(C3=CC=C([[email protected]]4CNCCC4)C=C3)N=C21)=O.O=S(C5=CC=C(C)C=C5)(O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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