Olaparib (AZD2281)

Name: Olaparib (AZD2281)
SKU: A10111
Price: 32 USD
Rating: 5 (31 reviews)

Catalog No.: A10111

PARP inhibitor

Adooq's Olaparib (AZD2281) has been cited by 31 publications

Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.

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Grouped product items
Product Name	Price	Stock
Olaparib 10mg	Special Price $32.00 Regular Price $40.00	In stock
Olaparib 25mg	Special Price $48.00 Regular Price $60.00	In stock
Olaparib 50mg	Special Price $56.00 Regular Price $70.00	In stock
Olaparib 100mg	Special Price $72.00 Regular Price $90.00	In stock
*Olaparib (AZD2281) 10mM 1mL in DMSO**	Special Price $60.80 Regular Price $76.00	In stock
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Data Sheet

SDS

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Adooq Products cited in reputable paper

Adooq's Olaparib (AZD2281) has been cited by 31 publications

Saptarshi Sinha, .et al. , Med Oncol, 2024, Jan 6;41(2):49 PMID: 38184505

Callum G Jones, .et al. , Cancers (Basel), 2024, Feb 21;16(5):863 PMID: 38473223

Aurelie Vanderlinden, .et al. , Br J Cancer, 2023, Nov;129(11):1829-1840 PMID: 37777579

Saptarshi Sinha, .et al. , Exp Cell Res, 2022, Nov 1;420(1):113338 PMID: 36075449

Subhajit Chatterjee, .et al. , J Cancer Res Clin Oncol, 2022, Dec;148(12):3521-3535 PMID: 35962813

Yuki Uchihara, .et al. , Mol Cell, 2022, Jul 21;82(14):2557-2570 PMID: 35594857

Ji-Ye Kim, .et al. , Cell Death Dis, 2022, Mar 15;13(3):239 PMID: 35293383

Emad Matanes, .et al. , Front Oncol, 2021, Oct 27;11:745981 PMID: 34778062

Shino Endo, .et al. , Cancer Res Commun, 2021, 1(2): 90-105

Yan Baglo, .et al. , Transl Oncol, 2021, Nov;14(11):101198 PMID: 34418731

Joseph M Gozgit, .et al. , Cancer cell, 2021, Jul 22;S1535-6108(21)00340-8 PMID: 34375612

Sefinew Molla, .et al. , DNA Repair (Amst), 2021, Jun 10;105:103157 PMID: 34144488

Jianming Wang, .et al. , Cell Rep, 2021, Feb 16;34(7):108759 PMID: 33596418

Ai Ito, .et al. , Biogerontology, 2021, Feb;22(1):119-131 PMID: 33216250

Tim J Wigle, .et al. , Cell Chem Biol, 2020, Jul 16;27(7):877-887 PMID: 32679093

Ali Divan, .et al. , Pharmacol Res Perspect, 2020, Apr; 8(2): e00586 PMID: 32342655

Jianwei Dou, .et al. , J Sep Sci, 2020, Dec 4 PMID: 33275824

Sai Dimple Manavitha Gullipalli, .et al. , Int. J. Adv. Pharm. Biotech, 2020, 6(2) 01-08

Chao Zhang, .et al. , J Atheroscler Thromb, 2020, Sep 25 PMID: 32981917

Wigle TJ, .et al. , SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104

Wang Q, .et al. , Cancer Med, 2019, Dec 21 PMID: 31863638

Molla S, .et al. , Pathol Oncol Res, 2019, Nov 25 PMID: 31768967

Alvin Z.Lu, .et al. , Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269

Bian C, .et al. , Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937

HC de Silva, .et al. , Cell Mol Life Sci, 2019, 1-16 PMID: 30725116

Kamada Y, .et al. , Fitoterapia, 2018, Sep;129:94-101 PMID: 29928967

2018, .et al. , FEBS Open Bio, 2018, Jun; 8(6): 1001-1012 PMID: 29928579

Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Hiro Sato, .et al. , Nat Commun, 2017, 8: 1751 PMID: 29170499

Charles-André Philip, .et al. , BMC Cancer, 2017, 17: 638 PMID: 28886696

Rulina AV, .et al. , Cell Death Dis, 2016, Dec 1;7(12):e2505 PMID: 27906189

Biological Activity

Discription

Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.

Targets

Target	Value

Product Information

Catalog Num	A10111
Formula	C24H23FN4O3
Molecular Weight	434.5
CAS Number	763113-22-0
SMILES	C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Synonyms	KU-0059436
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	Warmed: 74 mg/mL (170.32 mM)
	Water	<1 mg/mL
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.01 mL	115.07 mL	230.15 mL
0.5 mM	4.6 mL	23.01 mL	46.03 mL
1 mM	2.3 mL	11.51 mL	23.01 mL
5 mM	0.46 mL	2.3 mL	4.6 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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