Olaparib (AZD2281)

Catalog No.: A10111

PARP inhibitor

Olaparib (AZD2281) Chemical Structure

CAS NO. 763113-22-0

Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.

Availability: In stock

Package Price Qty
10 mg
$40.00
25 mg
$60.00
50 mg
$70.00
100 mg
$90.00
10mM * 1mL in DMSO
$76.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
Targets
PARP2 (Cell-free assay) PARP1 (Cell-free assay) Tankyrase-1 (Cell-free assay)
1 nM5 nM1.5 μM
In vitro (25°C) DMSO 86 mg/mL (197.94 mM)
Water 0.002 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.01 mL 115.07 mL 230.15 mL
0.5 mM 4.6 mL 23.01 mL 46.03 mL
1 mM 2.3 mL 11.51 mL 23.01 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

*The above data is based on the productmolecular weight 434.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10111
Actions Inhibitor
M. Wt 434.5
Formula C24H23FN4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 763113-22-0
Synonyms KU-0059436
SMILES C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

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