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Biological Activity
NU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells.
Targets
| PARP | ||||
| 400 nM |
| In vitro (25°C) | DMSO | 34 mg/mL (192.99 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 6 mg/mL | ||
| In vivo | 40% PEG 400+saline | 17 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 56.75 mL | 283.77 mL | 567.54 mL |
| 0.5 mM | 11.35 mL | 56.75 mL | 113.51 mL |
| 1 mM | 5.68 mL | 28.38 mL | 56.75 mL |
| 5 mM | 1.14 mL | 5.68 mL | 11.35 mL |
*The above data is based on the productmolecular weight 176.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15375 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 90417-38-2 |
| Formula | C9H8N2O2 |
| M. Wt | 176.2 |
| Purity | >98% |
| Synonyms | NU1025, NU-1025 |
| SMILES | CC1=NC(=O)C2=C(N1)C(=CC=C2)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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