XAV 939

Catalog No.: A10994

PARP inhibitor

XAV 939

XAV 939 Chemical Structure

CAS NO. 284028-89-3

XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively).

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$120.00
50 mg
$180.00
100 mg
$280.00
10mM * 1mL in DMSO
$55.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Shizu Aikawa, .et al. Autotaxin-lysophosphatidic acid-LPA 3 signaling at the embryo-epithelial boundary controls decidualization pathways, EMBO J, 2017, Jul 14; 36(14): 2146-2160 PMID: 28588064
  • Mikaël M. Martino, .et al. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration, Nat Commun, 2016, 7: 11051 PMID: 27001940

Biological Activity

XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively).
Targets
TNKS2 (Cell-free assay) TNKS1 (Cell-free assay)
4 nM11 nM
In vitro (25°C) DMSO 12 mg/mL (38.42 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+corn oil 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.02 mL 160.1 mL 320.2 mL
0.5 mM 6.4 mL 32.02 mL 64.04 mL
1 mM 3.2 mL 16.01 mL 32.02 mL
5 mM 0.64 mL 3.2 mL 6.4 mL

*The above data is based on the productmolecular weight 312.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10994
Actions Inhibitor
CAS No. 284028-89-3
Formula C14H11F3N2OS
M. Wt 312.3
Purity >98%
Synonyms XAV939, XAV-939
SMILES C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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