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PJ 34 hydrochloride

Catalog No.: A12665

PARP inhibitor

PJ 34 hydrochloride

PJ 34 hydrochloride Chemical Structure

CAS NO. 344458-15-7

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$100.00
50 mg
$170.00
100 mg
$300.00
10mM * 1mL in DMSO
$79.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Alvin Z.Lu, .et al. Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation, Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269
  • Wigle TJ, .et al. Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes, SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104

Biological Activity

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
In vitro (25°C) DMSO 57 mg/mL (171.79 mM)
Water 57 mg/mL (171.79 mM)
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.14 mL 150.69 mL 301.39 mL
0.5 mM 6.03 mL 30.14 mL 60.28 mL
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL

*The above data is based on the productmolecular weight 331.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12665
Actions Inhibitor
CAS No. 344458-15-7
Formula C17H17N3O2.HCl
M. Wt 331.8
Purity >98%
Synonyms PJ34, PJ-34
SMILES CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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