AG-014699 (Rucaparib)

Catalog No.: A10045

PARP inhibitor

AG-014699 (Rucaparib)

AG-014699 (Rucaparib) Chemical Structure

CAS NO. 459868-92-9

AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.

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5 mg

Regular Price: $60.00

Special Price $48.00

25 mg

Regular Price: $220.00

Special Price $176.00

50 mg

Regular Price: $270.00

Special Price $216.00

100 mg

Regular Price: $422.00

Special Price $337.60

10mM * 1mL in DMSO

Regular Price: $110.00

Special Price $88.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Tahira Baloch, .et al. Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1, BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446

Biological Activity

AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.
Targets
PARP (Cell-free assay)
1.4 nM(Ki)
In vitro (25°C) DMSO 81 mg/mL (192.23 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.73 mL 118.65 mL 237.3 mL
0.5 mM 4.75 mL 23.73 mL 47.46 mL
1 mM 2.37 mL 11.87 mL 23.73 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10045
Actions Inhibitor
CAS No. 459868-92-9
Formula C19H18FN3O.H3PO4
M. Wt 421.4
Purity >98%
Synonyms AG014699, PF-01367338,AG-014447 (as free base)
SMILES CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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