MK-4827 (Niraparib)

Name: MK-4827 (Niraparib)
SKU: A11026
Price: 60 USD
Rating: 5 (5 reviews)

Catalog No.: A11026

PARP inhibitor

Adooq's MK-4827 (Niraparib) has been cited by 5 publications

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.

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Grouped product items
Product Name	Price	Stock	Qty
MK-4827 5mg	$60.00	In stock
MK-4827 10mg	$90.00	In stock

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Important Notice: For research use only. We do not sell to patients.

Data Sheet

SDS

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Adooq Products cited in reputable paper

Adooq's MK-4827 (Niraparib) has been cited by 5 publications

Joseph M Gozgit, .et al. , Cancer cell, 2021, Jul 22;S1535-6108(21)00340-8 PMID: 34375612

Ann-Katrin Hopp, .et al. , Molecular cell, 2021, Jan 21; 81(2): 340–354 PMID: 33450210

Bian C, .et al. , Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937

Tahira Baloch, .et al. , BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446

Khalid Hilmi, .et al. , Sci Adv, 2017, May; 3(5): e1601898 PMID: 28560323

Biological Activity

Discription

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.

Targets

Target	Value

Chemical Information

Catalog Num	A11026
Formula	C19H20N4O
Molecular Weight	320.4
CAS Number	1038915-60-4
SMILES	C1C[C@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
Synonyms	MK4827
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	60 mg/mL (187.27 mM)
	Water	Insoluble
	Ethanol	60 mg/mL (187.27 mM)
In vivo	10% DMSO+40% PEG 300+5% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.21 mL	156.05 mL	312.11 mL
0.5 mM	6.24 mL	31.21 mL	62.42 mL
1 mM	3.12 mL	15.61 mL	31.21 mL
5 mM	0.62 mL	3.12 mL	6.24 mL

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