MK-4827 (Niraparib)

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.
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Product Name Price Stock Qty
MK-4827 5mg
$60.00
In stock
MK-4827 10mg
$90.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's MK-4827 (Niraparib) has been cited by 5 publications
  • Joseph M Gozgit, .et al. , Cancer cell, 2021, Jul 22;S1535-6108(21)00340-8 PMID: 34375612
  • Ann-Katrin Hopp, .et al. , Molecular cell, 2021, Jan 21; 81(2): 340–354 PMID: 33450210
  • Bian C, .et al. , Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937
  • Tahira Baloch, .et al. , BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446
  • Khalid Hilmi, .et al. , Sci Adv, 2017, May; 3(5): e1601898 PMID: 28560323
  • Biological Activity
    Discription MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.
    Targets
    Target Value
    Product Information
    Catalog Num A11026
    Formula C19H20N4O
    Molecular Weight 320.4
    CAS Number 1038915-60-4
    SMILES C1C[C@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
    Synonyms MK4827
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 60 mg/mL (187.27 mM)
    Water Insoluble
    Ethanol 60 mg/mL (187.27 mM)
    In vivo 10% DMSO+40% PEG 300+5% Tween 80+ddH2O 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 31.21 mL 156.05 mL 312.11 mL
    0.5 mM 6.24 mL 31.21 mL 62.42 mL
    1 mM 3.12 mL 15.61 mL 31.21 mL
    5 mM 0.62 mL 3.12 mL 6.24 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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