MK-4827 (Niraparib)

Name: MK-4827 (Niraparib)
Brand: Adooq Bioscience
SKU: A11026
Rating: 100 (5 reviews)

Catalog No.: A11026

PARP inhibitor

Product Citations (5)

MK-4827 (Niraparib) Chemical Structure

CAS NO. 1038915-60-4

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.

Availability: In stock

Package	Price	Qty
5 mg	$60.00
10 mg	$90.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq MK-4827 (Niraparib)

Joseph M Gozgit, .et al. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity, Cancer cell, 2021, Jul 22;S1535-6108(21)00340-8 PMID: 34375612
Ann-Katrin Hopp, .et al. Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation, Molecular cell, 2021, Jan 21; 81(2): 340?C354 PMID: 33450210
Bian C, .et al. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression, Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937
Tahira Baloch, .et al. Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1, BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446
Khalid Hilmi, .et al. CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair, Sci Adv, 2017, May; 3(5): e1601898 PMID: 28560323

Biological Activity

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.

Solubility *

In vitro (25°C)	DMSO	60 mg/mL (187.27 mM)
	Water	Insoluble
	Ethanol	60 mg/mL (187.27 mM)
In vivo	10% DMSO+40% PEG 300+5% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.21 mL	156.05 mL	312.11 mL
0.5 mM	6.24 mL	31.21 mL	62.42 mL
1 mM	3.12 mL	15.61 mL	31.21 mL
5 mM	0.62 mL	3.12 mL	6.24 mL

*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11026
Actions	Inhibitor
CAS No.	1038915-60-4
Formula	C19H20N4O
M. Wt	320.4
Purity	>98%
Synonyms	MK4827
SMILES	C1C[[email protected]](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.