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- Joseph M Gozgit, .et al. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity, Cancer cell, 2021, Jul 22;S1535-6108(21)00340-8 PMID: 34375612
- Ann-Katrin Hopp, .et al. Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation, Molecular cell, 2021, Jan 21; 81(2): 340?C354 PMID: 33450210
- Bian C, .et al. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression, Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937
- Tahira Baloch, .et al. Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1, BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446
- Khalid Hilmi, .et al. CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair, Sci Adv, 2017, May; 3(5): e1601898 PMID: 28560323
Biological Activity
MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.
In vitro (25°C) | DMSO | 60 mg/mL (187.27 mM) | |
Water | Insoluble | ||
Ethanol | 60 mg/mL (187.27 mM) | ||
In vivo | 10% DMSO+40% PEG 300+5% Tween 80+ddH2O | 9 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 31.21 mL | 156.05 mL | 312.11 mL |
0.5 mM | 6.24 mL | 31.21 mL | 62.42 mL |
1 mM | 3.12 mL | 15.61 mL | 31.21 mL |
5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11026 |
---|---|
Actions | Inhibitor |
CAS No. | 1038915-60-4 |
Formula | C19H20N4O |
M. Wt | 320.4 |
Purity | >98% |
Synonyms | MK4827 |
SMILES | C1C[[email protected]](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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