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MK-4827 (Niraparib)

Catalog No.: A11026

PARP inhibitor

MK-4827 (Niraparib)

MK-4827 (Niraparib) Chemical Structure

CAS NO. 1038915-60-4

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.

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5 mg

Regular Price: $60.00

Special Price $48.00

10 mg

Regular Price: $90.00

Special Price $72.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Joseph M Gozgit, .et al. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity, Cancer cell, 2021, Jul 22;S1535-6108(21)00340-8 PMID: 34375612
  • Ann-Katrin Hopp, .et al. Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation, Molecular cell, 2021, Jan 21; 81(2): 340?C354 PMID: 33450210
  • Bian C, .et al. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression, Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937
  • Tahira Baloch, .et al. Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1, BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446
  • Khalid Hilmi, .et al. CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair, Sci Adv, 2017, May; 3(5): e1601898 PMID: 28560323

Biological Activity

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.
In vitro (25°C) DMSO 60 mg/mL (187.27 mM)
Water Insoluble
Ethanol 60 mg/mL (187.27 mM)
In vivo 10% DMSO+40% PEG 300+5% Tween 80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.21 mL 156.05 mL 312.11 mL
0.5 mM 6.24 mL 31.21 mL 62.42 mL
1 mM 3.12 mL 15.61 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL

*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11026
Actions Inhibitor
CAS No. 1038915-60-4
Formula C19H20N4O
M. Wt 320.4
Purity >98%
Synonyms MK4827
SMILES C1C[[email protected]](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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