MK-4827 (Niraparib)

Catalog No.: A11026

PARP inhibitor

MK-4827 (Niraparib)

MK-4827 (Niraparib) Chemical Structure

CAS NO. 1038915-60-4

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.

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5 mg
$60.00
10 mg
$90.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Bian C, .et al. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression, Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937
  • Tahira Baloch, .et al. Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1, BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446
  • Khalid Hilmi, .et al. CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair, Sci Adv, 2017, May; 3(5): e1601898 PMID: 28560323

Biological Activity

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.21 mL 156.05 mL 312.11 mL
0.5 mM 6.24 mL 31.21 mL 62.42 mL
1 mM 3.12 mL 15.61 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL

*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11026
Actions Inhibitor
M. Wt 320.4
Formula C19H20N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1038915-60-4
Synonyms MK4827
SMILES C1C[[email protected]](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N

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