AG14361

Catalog No.: A10046

PARP inhibitor

AG14361

AG14361 Chemical Structure

CAS NO. 328543-09-5

AG14361 is a potent PARP inhibitor, enhanced TMZ cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$170.00
50 mg
$550.00
100 mg
$900.00
10mM * 1mL in DMSO
$123.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Vimal Pandey, .et al. Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis, Scientific Reports, 2019, 9, Article number: 5012

Biological Activity

AG14361 is a potent PARP inhibitor, enhanced TMZ cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.
Targets
PARP1 (Cell-free assay)
<5 nM(Ki)
In vitro (25°C) DMSO 11 mg/mL (34.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.21 mL 156.05 mL 312.11 mL
0.5 mM 6.24 mL 31.21 mL 62.42 mL
1 mM 3.12 mL 15.61 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL

*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10046
Actions Inhibitor
CAS No. 328543-09-5
Formula C19H20N4O
M. Wt 320.4
Purity >98%
Synonyms AG-14361
SMILES CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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