Catalog No.
Product Name
Application
Product Information
Citations
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Sex Pheromone
Lasiol is an acyclic monoterpene alcohol that acts as a sex pheromone, primarily found in the mandibular gland secretions of the ant Lasius meridionalis. This compound plays a crucial role in chemical communication and reproductive behaviors within ant colonies. It is a valuable reagent for research applications focused on pheromone signaling and the study of social insect behavior. -
Insect Pheromone
(2Z,13Z)-Octadecadienyl acetate is a female pheromone known to attract male clearwing moths, thereby disrupting mating behaviors. Isolated from the Japanese persimmon clearwing moth (Synanthedon tenuis), this compound serves as a valuable tool for research in pest management and the study of insect communication. Its application in agricultural studies and insect behavior analysis provides essential insights into ecological interactions and pest control strategies. -
Insect Pheromone
(Z)-3-Decenol is a volatile insect sex pheromone primarily targeting male beetles. It exhibits strong attractant properties, facilitating reproductive behaviors and enhancing mating success in various beetle species. This compound is valuable for studies in insect behavior, ecology, and pest management research. -
Insect Pheromone
(Z)-5-Dodecen-1-ol is a female pheromone that targets insect communication pathways, specifically isolated from the pheromone glands of the rice leaf folder (Plusia festucae). It plays a crucial role in attracting male moths for mating purposes, making it valuable for research in chemical ecology and pest management. This compound can be utilized in studies focusing on insect behavior, pheromone signaling, and the development of environmentally friendly pest control strategies. -
Insect Pheromone
4-Methyl-5-nonanone is a species-specific sex pheromone known for its role in insect communication, particularly isolated from the Asian palm red weevil (Rhynehophorus ferrugineus). This compound is primarily involved in attracting mates, making it valuable for research in ecological and behavioral studies of insect pheromones. Its applications extend to pest control strategies and the development of bio-based insect attractants. -
Insect Pheromone
(Z)-3-Dodecen-1-ol functions as an insect sex pheromone, primarily targeting male sweet potato weevils (Cylas formicarius elegantulus). This compound is utilized in entomological research to study insect behavior and develop pest management strategies. Its effectiveness in attracting specific insect populations makes it valuable for ecological and agricultural applications. -
Ant Pheromone
4-Methyl-3-hexanol is a naturally occurring pheromone, primarily involved in ant communication. This compound plays a critical role in the signaling processes related to foraging, mating, and colony organization in various ant species. It serves as a valuable reagent for studies focused on social insect behavior and chemical ecology, providing insights into pheromone-mediated interactions within insect populations. -
Insect Pheromone
(2E)-Octadecenal is a female pheromone with a specific action on Lepidoptera insects, primarily isolated from female Tineola bisselliella. This compound plays a critical role in insect communication, facilitating mating behavior and attraction. It is commonly utilized in research applications focused on pest control, behavioral ecology, and the study of insect pheromones. -
Pheromone
(E)-10-Hexadecenal acts as a pheromone, primarily synthesized from the fruit-feeding yellow peach moth, Dichocrocis punctiferalis. This compound is essential for mediating chemical communication in insects, making it a valuable tool for studies in entomology and pheromone research. Its application extends to behaviors such as mating and foraging, providing insights into insect ecology and pest management strategies. -
Insect Pheromone
Cis-Verbenol is an insect pheromone known for its role in inhibiting aggregation and inducing dispersion in mountain pine beetles (Dendroctonus ponderosae). This compound can be isolated from pine engravers and is utilized in ecological and agricultural research to study behavioral responses in pest management strategies. Its application in entomological studies aids in understanding the dynamics of insect population control and habitat displacement. -
Male Euhyponomeutoides albithoracellus Attractant
(Z)-11-Tetradecenyl acetate primarily targets male Euhyponomeutoides albithoracellus as a sex pheromone component. This compound elicits significant electrophysiological responses in male antennal receptors, demonstrating its effectiveness as an attractant. When paired with (E)-11-tetradecenyl acetate at specific E:Z isomer ratios, (Z)-11-tetradecenyl acetate maximizes attraction levels. Its applications encompass research in sustainable pest control strategies, including monitoring and mating disruption. -
SGK1 Inhibitor
SI-113 is an inhibitor of SGK1, demonstrating an IC50 of 600 nM. This compound is known to induce autophagy, making it a valuable tool for studying cellular mechanisms related to SGK1 activity. It has potential applications in research areas such as cancer biology and neurodegenerative diseases, where modulation of autophagy may be beneficial. -
SGK1 Inhibitor
SGK1-IN-4 is a selective inhibitor of Serum/Glucocorticoid-regulated Kinase 1 (SGK1), demonstrating oral bioactivity. This compound has potential applications in the study of osteoarthritis, targeting pathways involved in inflammation and cellular signaling. Its ability to modulate SGK1 activity makes it a valuable tool for investigating SGK1's role in various biological processes and disease states. -
SGK1 Inhibitor
SGK1-IN-2 is a selective inhibitor of serum and glucocorticoid-regulated kinase 1 (SGK1), characterized by an IC50 value of 5 nM at an ATP concentration of 10 μM. This compound effectively regulates SGK1 activity, influencing various cellular processes such as cell survival, proliferation, and metabolism. SGK1-IN-2 is valuable for research applications focused on cancer biology, cardiovascular diseases, and metabolic disorders. -
SGK1 Inhibitor
SGK1-IN-3 is a potent selective inhibitor of SGK1, exhibiting an IC50 of less than 1 μM. This compound demonstrates significant inhibitory activity, making it a valuable tool for investigating the role of SGK1 in various biological processes. Its application in research may provide insights into the mechanisms underlying osteoarthritis and contribute to the development of novel therapeutic strategies. -
SGK3 ligand-linker Conjugate
308-R-C4-PEG3-C1-Boc is a SGK3 ligand-linker conjugate designed for use in the synthesis of PROTAC SGK3 degrader-2. This compound facilitates targeted protein degradation by effectively linking the SGK3 ligand with a degradation mechanism. Its application in chemical research is particularly valuable for studies involving SGK3 modulation and related cellular pathways. -
SGK1 Inhibitor
SGK1-IN-6 is a selective inhibitor of SGK1, demonstrating a high potency with an IC50 value of 0.39 μM. This compound effectively suppresses tumor growth in the PC3 xenograft model in BALB/c nude mice while exhibiting no significant toxicity. SGK1-IN-6 is ideal for research applications focused on cancer biology and the exploration of SGK1's role in tumorigenesis. -
PROTAC SGK3 Degrader
PROTAC SGK3 degrader-2 is a selective PROTAC designed to engage SGK3 while targeting its degradation pathways. Unlike its trans counterpart, this compound possesses a cis hydroxyl group in the VH032 moiety, preventing its interaction with the VHL E3 ligase. It exhibits inhibitory effects on SGK3, SGK1, and S6K1, with IC50 values of 0.6 μM, 1.4 μM, and 1.7 μM, respectively, but does not induce SGK3 degradation. PROTAC SGK3 degrader-2 serves as an essential control reagent in research examining the specific biological effects of SGK3-PROTAC1-mediated degradation. -
SGK1 Inhibitor
SGK1-IN-5 is a potent inhibitor of serum and glucocorticoid-regulated kinase 1 (SGK1) with an IC50 of 3 nM. This compound effectively inhibits SGK1-dependent phosphorylation of glycogen synthase kinase 3 beta (GSK3β) in U2OS cells, demonstrating an IC50 of 1.4 μM. SGK1-IN-5 is valuable for research applications related to osteoarthritis and rheumatism, contributing to the understanding of pathways involved in inflammatory and degenerative joint diseases. -
SHMT Inhibitor
(+)SHIN2 is a selective inhibitor of serine hydroxymethyltransferase (SHMT), a key enzyme involved in folate metabolism and one-carbon metabolism. This compound has been shown to enhance survival in mouse models of NOTCH1-driven acute lymphoblastic leukemia (T-ALL) when used in conjunction with Methotrexate. Additionally, (+)SHIN2 features an alkyne group that facilitates its use in click chemistry applications, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. -
SHMT1/2 Inhibitor
SHMT-IN-2 is a stereospecific inhibitor of human serine hydroxymethyltransferases SHMT1 and SHMT2, exhibiting IC50 values of 13 nM and 66 nM, respectively. This compound effectively inhibits the proliferation of various human cancer cell lines and demonstrates notable sensitivity towards B-cell lymphomas. SHMT-IN-2 serves as a valuable tool for research investigating metabolic pathways involved in cancer cell growth and treatment response. -
SHMT Inhibitor
SHMT-IN-1 is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT). This compound demonstrates significant antitumor activity, making it a valuable tool for research focused on cancer therapeutics and metabolic pathways. Its efficacy in inhibiting SHMT highlights its potential application in the study of malaria and related biological processes. -
SHMT Inhibitor
SHMT-IN-3 is a selective inhibitor of serine hydroxymethyltransferases SHMT1 and SHMT2, with an IC50 of 0.53 µM for human SHMT1. This compound demonstrates noncompetitive inhibition against serine, making it a valuable tool for studying metabolic pathways involving one-carbon metabolism. SHMT-IN-3 is useful for investigating the role of SHMT in various biological processes and may have applications in cancer research and other metabolic disorders. -
SHMT1 Inhibitor
SHMT-IN-4 is an inhibitor of serine hydroxymethyltransferase (SHMT1), demonstrating an IC50 value of 193.8 g a.i./ha. This compound interferes with amino acid synthesis and metabolism in plants by binding to SHMT1, leading to inhibited plant growth. Importantly, SHMT-IN-4 exhibits minimal toxicity to maize and honeybees, making it a viable option for agricultural research applications focusing on selective herbicide development. -
SCD1 Inhibitor
Sterculic acid is a selective inhibitor of stearoyl-CoA desaturase-1 (SCD1), targeting the delta-9 desaturase (Δ9D) activity. It demonstrates significant inhibitory potency with an IC50 value of 0.9 μM. This compound is useful in studies exploring metabolic disorders, lipid metabolism, and the role of SCD1 in various disease states. -
SCD1 Inhibitor
SCD1 inhibitor-4 is a selective inhibitor of stearoyl-CoA desaturase-1 (SCD1) with potent oral bioavailability. This compound is primarily utilized in research focused on metabolic disorders, particularly in the study of diabetes. Its ability to modulate lipid metabolism makes it a valuable tool for investigating the role of SCD1 in adipogenesis and insulin sensitivity. -
Ole1/SCD Inhibitor
YTX-465 is a potent inhibitor of stearoyl-CoA desaturase (Ole1/SCD), demonstrating IC50 values of 0.039 μM for Ole1 and 30.4 μM for SCD1. This compound is instrumental in studying the biochemical pathways involved in Parkinson's disease and other synucleinopathies. Its ability to modulate Ole1 and SCD1 activity enables a deeper investigation into lipid metabolism and its implications in neurodegenerative conditions. -
D5D Inhibitor
T-3364366 is a reversible, slow-binding inhibitor of delta-5 desaturase (D5D) with sub-nanomolar potency, showing IC50 values of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cell lines, respectively. This compound demonstrates significant inhibitory activity towards D5D (IC50 = 19 nM) while exhibiting excellent selectivity against delta-6 desaturase (D6D, IC50 = 6200 nM) and stearoyl-CoA desaturase (SCD, IC50 > 10000 nM). T-3364366 serves as a valuable tool for research into lipid metabolism and related disorders. -
SCD1/5 Inhibitor
SCD1/5-IN-1 is a selective inhibitor of stearoyl-CoA desaturase 1 and 5 (SCD1/5), which plays a critical role in lipid metabolism and fatty acid desaturation. This compound demonstrates potential biological activity in modulating lipid profiles and influencing cellular signaling pathways associated with various neurological diseases. SCD1/5-IN-1 is suitable for studies aimed at elucidating the role of SCD enzymes in neurological pathologies and metabolic disorders. -
SCD1 Inhibitor
SCD1 Inhibitor-3 is a potent and orally bioavailable inhibitor of stearoyl-CoA desaturase 1 (SCD1). This compound demonstrates significant efficacy in modulating lipid metabolism, making it valuable in the study of metabolic disorders such as obesity, type II diabetes, and dyslipidemia. Additionally, SCD1 Inhibitor-3 may have applications in researching skin conditions, including acne and certain cancers, by influencing cellular lipid profiles. -
SCD Inhibitor
Cbz-L-Trp-OH is a competitive inhibitor of stearoyl-CoA desaturase (SCD), exhibiting an IC50 of 2.5 μM and a Ki of 2.1 μM. This compound is valuable for studying lipid metabolism and exploring therapeutic interventions in metabolic disorders. Its ability to selectively inhibit SCD makes it a useful tool for investigating the role of fatty acid desaturation in various physiological and pathological processes. -
SCD Inhibitor
SW203668 TFA is an irreversible inhibitor of stearoyl CoA desaturase (SCD), exhibiting an IC50 of 54 nM. By covalently binding to SCD, it effectively depletes unsaturated fatty acids and induces cell death in sensitive cell types, particularly those expressing CYP4F11. This selective cytotoxicity renders SW203668 TFA particularly valuable in the research of non-small cell lung cancer (NSCLC), as it inhibits tumor growth in CYP4F11-expressing xenografts while sparing other cell types. Its unique mechanism makes it a potent tool for studying targeted therapies in cancer treatment. -
Herbicide
Flurtamone is a chiral herbicide that targets plant growth through the inhibition of specific metabolic pathways. It exhibits acute toxicity to the freshwater algae Selenastrum capricornutum, making it valuable for studies on herbicidal effects and aquatic ecosystem impact. Flurtamone can be utilized in research focused on the development of sustainable agricultural practices and environmental safety assessments. -
SCD1 Inhibtior
XEN103 is a selective inhibitor of stearoyl-CoA desaturase 1 (SCD1), exhibiting IC50 values of 14 nM and 12 nM against mouse SCD1 and human SCD1 in HepG2 cells, respectively. This compound plays a significant role in research related to obesity and type 2 diabetes by modulating lipid metabolism. Additionally, XEN103 has been shown to induce sebaceous gland atrophy in murine models, providing further avenues for study in dermatological and metabolic disorders. -
SCD1 Inhibitor
SCD1-IN-1 is a selective inhibitor of stearoyl-CoA desaturase 1 (SCD1), with an IC50 value of 5.8 nM. This compound is primarily used in research focused on dermatological conditions, where modulation of fatty acid metabolism may influence disease outcomes. SCD1-IN-1's ability to inhibit SCD1 makes it a valuable tool for studying the underlying mechanisms of skin-related pathologies and potential therapeutic approaches. -
SCD Inhibitor
SW203668 is an irreversible inhibitor of stearoyl CoA desaturase (SCD) with an IC50 of 54 nM. It covalently binds to SCD, leading to the depletion of unsaturated fatty acids and triggering cell death in sensitive cells. Notably, SW203668's effectiveness is influenced by the expression of CYP4F11, as its active form is generated through demethylation by this enzyme, resulting in selective toxicity towards CYP4F11-expressing non-small cell lung cancer (NSCLC) cells. Additionally, SW203668 has demonstrated the ability to inhibit tumor growth in immunodeficient mice with NSCLC xenografts while sparing CYP4F11-lacking cells and mouse skin sebocytes, making it a valuable tool for research on non-small cell lung cancer. -
SCD inhibitor
MK-8245 analog is a potent inhibitor of stearoyl-CoA desaturase (SCD), exhibiting an IC50 of 7 nM in rat SCD assays. This compound demonstrates significant antidiabetic and antidyslipidemic activities, making it a valuable tool for research in metabolic disorders. Its mechanism of action provides opportunities for investigating SCD-related pathways in various biological contexts. -
SCD Inhibitor
Cbz-D-Trp-OH is a competitive inhibitor of stearoyl-CoA desaturase (SCD), demonstrating an IC50 of 86 μM and a Ki value of 71 μM. This compound modulates lipid biosynthesis and is instrumental in studying lipid metabolism and related metabolic disorders. Its use is pertinent in research focused on understanding the role of SCD in obesity, diabetes, and cardiovascular diseases. -
SCD1 Inhibitor
SCD1 inhibitor-5 is a selective inhibitor of stearoyl-CoA desaturase-1 (SCD1), exhibiting IC50 values of 0.13 μM in H2122 cells and 31 μM in H1819 cells. This compound effectively reduces SCD1 activity, making it a valuable tool in cancer research. Its inhibition of lipid metabolism pathways can provide insights into tumor growth and proliferation mechanisms. -
STS Inhibitor
Estrone O-sulfamate is a potent inhibitor of steroid sulfatase (STS), a key enzyme involved in steroid hormone metabolism. It demonstrates significant inhibitory activity with IC50 values of 18 nM in placental microsomes and 0.83 nM in MCF-7 cells. This compound is valuable for research focused on cancer, as it helps elucidate the role of STS in tumorigenesis and hormone-driven malignancies. -
Steroid Sulfatase Inhibitor
Estradiol 3-sulfamate is a potent steroid sulfatase inhibitor, effectively targeting estrone sulfatase with an IC50 value of 251 nM and a Ki of 133 nM. This compound is recognized for its long-acting and orally active properties, making it a valuable reagent for research applications focused on hormone metabolism and endocrine signaling. Its ability to modulate sulfated steroid levels supports investigations into various biological processes, including cancer research and reproductive health studies. -
Steroid Sulfatase Inhibitor
KW-2581 is a selective steroid sulfatase (STS) inhibitor, exhibiting an IC50 of 4 nM. This compound effectively inhibits STS activity in ZR-75-1 cells with an IC50 of 13 nM, demonstrating significant impairment of E1S-stimulated cell growth at an IC50 of 0.18 nM. KW-2581 has shown the ability to inhibit sulfated estrogen-dependent proliferation of breast cancer cells both in vitro and in vivo, leading to tumor regression in E1S-induced models. This reagent is suitable for studies focused on hormone receptor-positive breast cancer and the role of steroid sulfatase in tumor biology. -
STS Inhibitor/ERα Modulator
SR-16157 is a dual-action steroid sulfatase (STS) inhibitor and selective estrogen receptor alpha (ERα) modulator, with an IC50 of 0.1 µM. This compound displays potent STS inhibitory and anti-estrogenic effects in breast cancer cells, making it a valuable tool for understanding the role of estrogen signaling in cancer progression. SR-16157 is applicable in breast cancer research, particularly in studies exploring therapeutic strategies targeting estrogen metabolism and receptor modulation. -
Steroid Sulfatase Inhibitor
Steroid sulfatase-IN-10 is a potent inhibitor of steroid sulfatase, exhibiting an IC50 range of 0.03-0.27 µM. This compound is valuable for investigating its role in various inflammatory conditions, including rheumatoid arthritis, type 1 and type 2 diabetes, and systemic lupus erythematosus. Its selective inhibition of steroid sulfatase makes it a useful tool in exploring therapeutic avenues for these diseases. -
Steroid sulfatase/17β-HSD1 Inhibitor
Steroid sulfatase/17β-HSD1-IN-3 is a potent dual inhibitor targeting steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). It irreversibly inhibits human STS activity with an IC50 of 27 nM, demonstrating significant efficacy. This compound is suitable for research focused on endometriosis and other estrogen-dependent diseases, facilitating the exploration of therapeutic strategies in these areas. -
STS Inhibitor
Steroid Sulfatase-IN-2 is a potent steroid sulfatase (STS) inhibitor, exhibiting an IC50 value of 109.5 nM. This compound enables research into hormone-dependent cancers, particularly those driven by estrogen, such as breast and endometrial cancer. Its role as an STS inhibitor makes it a valuable tool for understanding the molecular mechanisms underlying these cancer types and exploring potential therapeutic strategies. -
STS Inhibitor
Steroid sulfatase-IN-8 is a potent steroid sulfatase (STS) inhibitor, demonstrating a pharmacological IC50 of 1 nM in PM models and 0.025 nM in JEG-3 cells. This compound effectively interferes with steroid metabolism, making it a valuable tool for investigating steroid-related pathways. Its application extends to studies on hormone-dependent cancers and other conditions linked to altered steroid levels. -
Steroid Sulfatase Inhibitor
DU-14 is a potent inhibitor of steroid sulfatase, exhibiting an IC50 of 55.8 nM. It effectively reduces MCF-7 cell proliferation, with an IC50 value of 38.7 nM. Additionally, DU-14 demonstrates neuroprotective properties against neurotoxic amyloid-beta (Aβ), indicating its potential to up-regulate endogenous dehydroepiandrosterone sulfate (DHEAS) and alleviate Aβ-induced deficits in spatial memory and synaptic plasticity. This compound is valuable for research in cancer biology and neurodegenerative diseases. -
STS Inhibitor
Steroid sulfatase-IN-4 is an irreversible inhibitor of steroid sulfatase (STS), exhibiting an IC50 of 25 nM against human STS. This compound is primarily utilized in research focused on endometriosis, offering potential insights into the role of STS in disease progression and therapeutic interventions. Its selective inhibition of STS facilitates the exploration of hormonal pathways involved in reproductive health. -
STS Inhibitor
Steroid sulfatase-IN-3 is a potent inhibitor of steroid sulfatase (STS) with an IC50 value of 25.8 nM. This compound exhibits significant antiproliferative activity against T-47D estrogen-dependent breast cancer cells, demonstrating an IC50 of 1.04 µM. Steroid sulfatase-IN-3 is primarily utilized in cancer research to explore the role of STS in hormone-dependent tumor progression and treatment resistance.
