Catalog No.
Product Name
Application
Product Information
Citations
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Xanthine Oxidase Inhibitor
Angexostat is a potent xanthine oxidase inhibitor, effectively blocking its enzymatic activity. With demonstrated high permeability, Angexostat inhibits CYP2C9 with an IC50 of 18.1 μM. This compound is valuable in research focused on xanthine oxidase-related conditions, including hyperuricemia and gout, providing insights into potential therapeutic strategies. -
XOR Inhibitor
Xanthine oxidoreductase-IN-4 is a potent inhibitor of xanthine oxidoreductase (XOR) with an IC50 value of 29.3 nM. This compound demonstrates significant inhibitory activity, making it a valuable tool for investigating metabolic disorders associated with hyperuricemia. Xanthine oxidoreductase-IN-4 can facilitate research aimed at understanding the role of XOR in uric acid metabolism and related conditions. -
Xanthine Oxidase Inhibitor
Xanthine oxidase-IN-10 is a potent inhibitor of xanthine oxidase, an enzyme involved in the production of reactive oxygen species. By inhibiting this enzyme, Xanthine oxidase-IN-10 demonstrates potential anti-inflammatory and antioxidant properties. This reagent is valuable for research applications in understanding gout, hyperuricemia, and oxidative stress-related conditions. -
Xanthine Oxidase Inhibitor
(+/-)-Epicatechin is a xanthine oxidase inhibitor with an IC50 value of 982.14 μM. This compound, found in Semen Plantaginis (Plantago seed), showcases potential in research related to hyperuricemia and gout. Its ability to modulate xanthine oxidase activity makes it a valuable tool for investigating mechanisms underlying uric acid metabolism and associated pathologies. -
XO Inhibitor
Tetrahydroamentoflavone is a potent xanthine oxidase (XO) inhibitor, demonstrating significant inhibitory activity with IC50 and Ki values of 92 nM and 0.982 μM, respectively. This compound has potential applications in the study of inflammatory disorders and gout, making it a valuable tool for researchers investigating these conditions. Its ability to modulate XO activity positions it as a promising candidate for further exploration in therapeutic contexts. -
XOD Inhibitor
Xanthine oxidase-IN-9 is a selective inhibitor of xanthine oxidase (XOD), exhibiting an IC50 value of 31.81 μM. This compound is instrumental in studying disorders associated with increased XOD activity, including gout and oxidative stress-related conditions. Its biological activity makes it a valuable tool in biochemical research aimed at developing therapeutic strategies targeting purine metabolism and reactive oxygen species. -
Xanthine Oxidase Inhibitor
Prudomestin is a potent xanthine oxidase inhibitor derived from the heartwood of Prunus domestica. With an IC50 of approximately 6 µM, it exhibits significant inhibitory activity against XO, a key enzyme involved in purine metabolism and the production of reactive oxygen species. This compound is valuable for research applications focused on oxidative stress, gout, and related inflammatory conditions. -
Xanthine Oxidase Inhibitor
Xanthine oxidase-IN-4 is a potent inhibitor of xanthine oxidase (XO), exhibiting an IC50 of 0.039 μM. This compound demonstrates significant hypouricemic activity in potassium oxonate-induced models of hyperuricemia, making it suitable for investigations related to hyperuricemia and gout. Xanthine oxidase-IN-4 is valuable for researchers studying metabolic disorders and the pharmacological management of gout. -
Antithrombotic Agent
5,6,7-Trihydroxy-4'-methoxyflavone, also known as 4'-O-Methylscutellarein, is a flavonoid that acts primarily as an antithrombotic agent. It exhibits both antithrombotic and antioxidant properties, with an IC50 of 25.29 µM for scavenging DPPH free radicals. Additionally, this compound effectively inhibits H2O2-induced damage in PC12 cells, making it a valuable reagent for studying cerebrovascular disorders and related conditions. -
Xanthine Oxidase Inhibitor
Protosappanin A dimethyl acetal is a homoisoflavonoid that acts as a competitive inhibitor of xanthine oxidase. This compound demonstrates significant xanthine oxidase inhibitory activity, with an IC50 value of 50.7 μM. It is isolated from the plant species Caesalpinia sappan and is applicable in research focused on oxidative stress and related metabolic disorders. -
Xanthine oxidase Inhibitor
Xanthine oxidase-IN-15 is a selective inhibitor of xanthine oxidase (XO) with an IC50 of 0.13 μM. This compound functions by forming a stable interaction at the active site of XO, effectively inhibiting its catalytic activity. Xanthine oxidase-IN-15 is primarily utilized in research related to hyperuricemia and gout, offering insights into the management and treatment of these conditions. -
Xanthine Oxidase Inhibitor
Renierol is an orally active inhibitor of xanthine oxidase (XO), a critical enzyme involved in purine metabolism. It exhibits notable urate-lowering activity, making it valuable for research related to gout and hyperuricemia. This compound is essential for studying the role of XO in oxidative stress and related pathologies. -
Xanthine Oxidase Inhibitor
5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione is a potent inhibitor of xanthine oxidase, an enzyme involved in the oxidative metabolism of purines. This compound exhibits significant biological activity in the reduction of uric acid levels, making it relevant for studies related to hyperuricemia and gout. Research applications include investigations into the mechanistic pathways of oxidative stress and potential therapeutic interventions for related disorders. -
XO Inhibitor
BOF-4272 is a selective inhibitor of xanthine oxidase and xanthine dehydrogenase. This compound is primarily utilized in research focused on hyperuricemia and related disorders. By inhibiting uric acid production, BOF-4272 serves as a valuable tool for studying gout and other conditions associated with elevated uric acid levels. -
Xanthosine oxidase Inhibitor
Hydroxyakalone is a potent inhibitor of xanthosine oxidase (XOD, EC 1.2.3.2), exhibiting an IC50 value of 4.6 μM. This compound is useful in research applications focused on oxidative stress and related metabolic pathways. Its ability to inhibit XOD may provide insights into the management of conditions associated with elevated levels of xanthine and uric acid. -
Xanthine Oxidase Inihibitor
Amflutizole is a potent inhibitor of xanthine oxidase, effectively reducing the formation and release of free radicals. This compound demonstrates protective effects in models of cerebral ischemia/reperfusion, making it a valuable tool for research into oxidative stress and related neuroprotective strategies. Its ability to modulate xanthine oxidase activity positions it for applications in studying various neurological conditions and therapeutic interventions. -
Xanthine Oxidase Inhibitor
Xanthine oxidase-IN-14 is a potent inhibitor of xanthine oxidase, demonstrating an IC50 value greater than 100 μM. This compound has shown significant anti-proliferative activity against cancer cell lines, including MCF-7, NCI-H460, and SF-268, with inhibition occurring at an IC50 greater than 150 μM. It serves as a valuable tool for exploring the role of xanthine oxidase in cancer biology and potential therapeutic applications. -
Xanthine Oxidase Inhibitor
Xanthine oxidase-IN-22 is a potent inhibitor of xanthine oxidase (XO) with an IC50 of 0.0034 μM, demonstrating a mixed-type inhibition profile. This compound effectively lowers serum uric acid levels in murine models. Xanthine oxidase-IN-22 is suitable for research applications focused on hyperuricemia and gout management. -
Xanthine Oxidase Inhibitor
Xanthine oxidase-IN-1 is a potent inhibitor of xanthine oxidase, demonstrating an IC50 of 6.5 nM. This compound is valuable for research applications focusing on the modulation of purine metabolism and the investigation of conditions associated with oxidative stress, such as gout and cardiovascular diseases. Its ability to effectively inhibit xanthine oxidase makes it a useful tool in exploring therapeutic strategies for these disorders. -
Glycosyl Hydrolase
Beta-glucuronidase (Escherichia coli) is a glycosyl hydrolase that catalyzes the hydrolysis of β-glucuronic acid and sulfate esters, resulting in the release of β-glucuronate. This enzyme is crucial for the study of drug metabolism and detoxification pathways, particularly in the analysis of xenobiotic and endogenous compounds in urine and other biological fluids. Its activity is essential in research applications involving pharmacokinetics and clinical diagnostics. -
β-Glucuronidase Substrate
4-Nitrophenyl β-D-glucuronide serves as a chromogenic substrate for the enzyme β-glucuronidase. Upon hydrolysis by β-glucuronidase, it produces a colored product, enabling easy detection and quantification. This compound is widely utilized in biochemical assays for studying enzyme kinetics, assessing enzyme activity, and exploring glucuronidation processes in various biological contexts. -
β-Glucuronidase Inhibitor
Saccharic acid is a competitive inhibitor of β-glucuronidase, a key enzyme involved in the hydrolysis of glucuronides. This compound effectively slows the hydrolysis of l-ortho-hydroxyphenylazo-2-naphthol glucuronide in frozen mouse kidney sections, making it a valuable tool for studying glucuronidation processes. While it demonstrates utility in renal studies, it does not influence liver regeneration following injury or growth in infant mice, ensuring specific applications in biochemical research. -
β-glucuronidase Inhibitor
Ganoderenic acid A is a lanostane-type triterpene that functions as a potent inhibitor of β-glucuronidase. This compound demonstrates significant hepatoprotective properties, particularly in mitigating liver injury induced by carbon tetrachloride (CCl4). Ganoderenic acid A is valuable for research into liver disease mechanisms and the development of protective strategies against hepatotoxicity. -
β-glucuronidase Substrate
Phenolphthalein glucuronide sodium is a specific substrate for β-glucuronidase, an enzyme involved in the hydrolysis of glucuronides. This compound is utilized in biochemical assays to measure β-glucuronidase activity, which is significant in various physiological and pathological processes. Its application extends to drug metabolism studies and understanding liver function, contributing to research in toxicology and pharmacology. -
Macrophage-activating Agent
TAN-1030A is an indolocarbazole alkaloid that functions as a macrophage-activating agent. It induces morphological changes in murine macrophage cell lines, such as Mm 1, and enhances their phagocytic activity, Fc gamma receptor expression, and β-glucuronidase activity in both Mm 1 and J774A.1 cell lines. TAN-1030A can effectively activate macrophage functions in in vivo models, making it a valuable tool for studying immune responses and macrophage biology. -
β-glucuronidase Substrate
6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium is a chromogenic substrate specifically designed for β-glucuronidase activity. Upon enzymatic cleavage, it generates a distinctive salmon-colored precipitate, facilitating the detection and quantification of β-glucuronidase activity in biological samples. This reagent is ideal for applications in enzymology and biochemical assays, providing a reliable means to study glucuronidation processes in various research settings. -
β-Glucuronidase Substrate
Naphthol AS-OL is a substrate for β-glucuronidase, enabling the assessment of enzyme activity in biochemical research. As a key tool in glucuronidation studies, it facilitates the detection of β-glucuronidase activity, which is important for understanding drug metabolism and various physiological processes. This compound is instrumental in assays that quantify β-glucuronidase levels, contributing to studies in pharmacokinetics and enzymology. -
Detection Substrate
5-Bromo-4-chloro-1H-indol-3-yl nonanoate serves as a fluorescent substrate for enzyme detection. Upon reaction with specific enzymes, it generates a detectable fluorescent product, making it particularly effective for monitoring β-galactosidase, α-chymotrypsin, and β-glucuronidase activities. This reagent is widely utilized in biochemical assays and enzyme activity studies, providing valuable insights in various research applications. -
β-glucuronidase Inhibitor
4'',5''-Dehydroisopsoralidin is a potent inhibitor of β-glucuronidase, with an IC50 value of 6.3 μM. This compound exhibits significant anti-inflammatory and antioxidant properties, making it a valuable tool for research focused on inflammation and various cancer pathways. Its inhibition of β-glucuronidase can help elucidate the mechanisms underlying these biological processes. -
Fluorogenic Substrate
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrate utilized for the detection of β-glucuronidase activity. Upon enzymatic hydrolysis, it emits fluorescence at an excitation wavelength of 362 nm and an emission wavelength of 445 nm. This compound serves as an effective tool in research applications aimed at quantifying β-glucuronidase activity and monitoring Escherichia coli populations. -
β-glucuronidase Inhibitor
β-Glucuronidase-IN-4 is a non-competitive inhibitor of β-glucuronidase, exhibiting an IC50 of 2.68 μM and a Ki value of 1.64 μM. This compound has demonstrated potential in alleviating gastrointestinal adverse events associated with Escherichia coli infections by effectively inhibiting the activity of E. coli β-glucuronidase. Its application is relevant for research focused on gut microbiome interactions and microbial enzyme inhibition. -
MAO-B Inhibitor
MAO-B-IN-9 is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) that effectively penetrates the blood-brain barrier, exhibiting an IC50 of 0.18 μM. This compound demonstrates neuroprotective effects by preventing Aβ1-42-induced neuronal cell death, potentially through its ability to inhibit Aβ1-42 aggregation. Additionally, MAO-B-IN-9 serves as a click chemistry reagent, featuring an alkyne group that readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions for versatile applications in chemical biology research. -
NMT Inhibitor
Zelenirstat is a potent dual inhibitor of N-myristoyltransferase (NMT), exhibiting IC50 values of 5 nM for NMT1 and 8 nM for NMT2. This orally active small molecule induces apoptosis in cancer cells and demonstrates anti-cancer activity by inhibiting early B cell receptor (BCR) signaling. Zelenirstat is a valuable tool for investigating the mechanisms underlying malignant lymphoma and other related malignancies. -
N-myristoyltransferase Inhibitor
LY134046 is an inhibitor of N-myristoyltransferase (NMT), primarily targeting norepinephrine N-methyltransferase in cardiovascular research. This compound produces sustained reductions in mean arterial blood pressure and heart rate without significantly altering norepinephrine concentrations in the rat brain. Notably, LY134046 does not engage with adrenergic or cholinergic receptors, indicating that its hypotensive and bradycardic effects operate independently of neurogenic tension. At a dosage of 40 mg/kg/day, LY134046 leads to significant inhibition of NMT activity in the hypothalamus and brainstem, thereby inducing central norepinephrine depletion. -
NMT Inhibitor
NMT-IN-8 is a potent and selective inhibitor of N-myristoyl transferase (NMT), exhibiting an IC50 value of less than 10 nM. It effectively disrupts the catalyzed protein N-myristoylation by binding to the peptide binding pocket of NMT, thereby influencing critical biological pathways including protein trafficking, signal transduction, and viral replication. This compound is particularly relevant for research applications in oncology, such as MYC-addicted cancers and B-cell lymphoma, as well as in the study of infectious diseases, including malaria, HIV, and rhinovirus infections. -
NAMPT Activator
NAT is a potent NAMPT activator, exhibiting an EC50 of 5.7 μM and a KD of 379 nM. As the rate-limiting enzyme in the NAD salvage pathway, NAMPT is crucial for maintaining cellular NAD levels, making it a valuable target for studying diseases linked to NAD depletion, such as neurodegenerative disorders. This compound is essential for research aiming to explore therapeutic strategies that enhance NAD metabolism and combat related pathologies. -
NAMPT Activator
Nampt Activator-3 is a potent NAD+ biosynthesis enhancer targeting nicotinamide phosphoribosyltransferase (NAMPT). With an EC50 of 2.6 μM and a KD of 132 nM, it effectively protects cultured cells from FK866-mediated toxicity. Additionally, Nampt Activator-3 demonstrates substantial neuroprotective effects in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN), indicating its potential applicability in neuroprotection research and therapeutic interventions. -
NAMPT Inhibitor
Nampt-IN-10 TFA is a potent inhibitor of Nicotinamide Phosphoribosyltransferase (NAMPT). It exhibits significant cellular potency against A2780 and CORL23 cell lines, with IC50 values of 5 nM and 19 nM, respectively. This compound serves as a promising non-antimitotic payload for antibody-drug conjugates (ADCs) in cancer research, highlighting its potential in therapeutic applications targeting NAMPT-related metabolic pathways. -
Nampt Inhibitor
Nampt-IN-15 is an inhibitor of nicotinamide adenine dinucleotide (NAD) biosynthesis through the inhibition of nicotinamide phosphoribosyltransferase (Nampt). It exhibits potent cytotoxicity in various cancer cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13, with IC50 values of 38.5 nM, 8 nM, 8.5 nM, and 7 nM, respectively. This compound is valuable for research applications focused on cancer metabolism and therapeutic strategies targeting NAMPT in tumor cells. -
NAMPT Activator
Nampt activator-1 is a potent activator of Nicotinamide phosphoribosyltransferase (NAMPT), exhibiting an EC50 in the range of 3.3 to 3.7 μM. This compound enhances NAMPT activity, which plays a crucial role in NAD+ biosynthesis. It has potential applications in research focused on metabolic disorders, neuroprotection, and aging-related studies, making it a valuable tool for investigating NAD+ metabolism and its implications in cellular energetics. -
NAMPT Inhibitor
GNE-618 is a potent inhibitor of nicotinamide phosphoribosyl transferase (NAMPT) with an IC50 of 6 nM. By depleting cellular NAD levels, GNE-618 induces apoptosis in tumor cells, exhibiting significant anti-tumor activity. This compound is primarily applied in cancer research, facilitating the study of NAD metabolism and its implications in oncology. -
NAMPT Activator
Nampt activator-2 is a potent NAMPT activator, demonstrating an EC50 value of 0.023 μM. This compound also exhibits moderate inhibitory activity against cytochrome P450 enzymes CYP2C9 (0.060 μM), CYP2D6 (0.41 μM), and CYP2C19 (0.59 μM). Its primary application lies in enhancing NAMPT-mediated pathways, making it a valuable tool for research in metabolic regulation and potential therapeutic interventions. -
NAMPT Activator
Nampt activator-4 is a potent activator of nicotinamide phosphoribosyltransferase (NAMPT), exhibiting an EC50 of 0.058 μM in human cells and a binding affinity (Ka) of 0.08538 μM. By binding to the rear channel of NAMPT, it enhances enzyme activity and counteracts feedback inhibition caused by nicotinamide and NAD+, leading to increased cellular levels of nicotinamide adenine dinucleotide (NAD+). Nampt activator-4 can effectively shift the concentration-response curve of NAMPT inhibitors, making it a valuable tool for research into type 2 diabetes and metabolic regulation. Its stability in liver microsomes and impact on cytochrome P450 activity (CYP2D6 and CYP3A4) further support its potential utility in pharmacological studies. -
NAMPT Inhibitor
GNE-617 hydrochloride is a potent inhibitor of NAMPT (Nicotinamide adenine dinucleotide biosynthesis regulator) with an IC50 of 5 nM. This compound effectively disrupts NAMPT enzymatic activity, leading to decreased levels of NAD+ in cellular systems. GNE-617 has demonstrated significant efficacy in various xenograft cancer models, making it a valuable tool for investigating cancer metabolism and the therapeutic potential of targeting NAD+ synthesis. -
NAMPT Degrader
LYP-8 is a highly potent NAMPT degrader that achieves up to 97% degradation of NAMPT at a concentration of 0.5 μM in SKOV-3 cells. Its mechanism of action involves selective targeting for degradation, leading to significant anti-cancer effects both in vitro and in vivo. This compound is valuable for research applications focused on the modulation of NAD+ metabolism and the exploration of therapeutic strategies in cancer treatment. -
NAMPT Inhibitor
A-1293201 is a potent NAMPT inhibitor that demonstrates antitumor activity by reducing total cellular NAD+/NADH levels. This reduction leads to significant ATP depletion, ultimately resulting in the induction of cancer cell death. Additionally, A-1293201 effectively addresses the acquired resistance mechanism associated with the NAMPT Y18 mutant, providing a promising avenue for research in cancer treatment. -
NAMPT Inhibitor
LB-60-OF61 hydrochloride is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), demonstrating significant cytotoxic effects. This compound shows selective activity against MYC-overexpressing cell lines, making it a valuable tool in cancer research. Its specific targeting of NAMPT allows for investigations into pathways related to cellular metabolism and cancer cell survival. -
NAMPT Inhibitor
Nampt-IN-9 is a potent inhibitor of nicotinamide adenine dinucleotide (NAD+) biosynthesis via the enzyme NAMPT. It exhibits significant anticancer activity and has potential applications in research focusing on pancreatic ductal adenocarcinoma. This compound serves as a valuable tool for studying the metabolic pathways and therapeutic strategies related to cancer treatment. -
NAMPT activator
JGB-1-155 is a positive allosteric modulator of nicotinamide phosphoribosyltransferase (NAMPT), displaying an EC50 of 3.29 μM. This compound enhances NAD+ production, thereby mitigating oxidative stress in THP-1 human monocytes. Additionally, JGB-1-155 is effective in reducing TNFα-induced reactive oxygen species (ROS) levels in HT-22 neuronal cells, positioning it as a valuable tool for research into cellular stress responses and metabolic regulation. -
NAMPT Inhibitor
Nampt-IN-13 is a selective inhibitor of nicotinamide adenine dinucleotide (NAD+) biosynthesis through the inhibition of nicotinamide phosphoribosyltransferase (NAMPT). This compound demonstrates significant anti-proliferative effects and is utilized in the study of tumor metabolism and cancer therapy. Its application is particularly relevant in the synthesis of antibody-drug conjugates (ADCs) for targeted cancer treatment research.
