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Catalog No.
Product Name
Application
Product Information
Product Citation
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hepatoselective glucokinase activator
PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively. -
p32-kinase activator
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator. -
NAMPT activator
P7C3-A20 is a potent neuroprotective agent.- Oku H, .et al. , Invest Ophthalmol Vis Sci, 2017, Sep 1;58(11):4877-4888 PMID: 28973334
- Oku H, .et al. , Jpn J Ophthalmol, 2017, Mar;61(2):195-203 PMID: 28032230
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NAMPT activator
(R)-P7C3-Ome is a methoxy derivative of parent compound P7C3, an aminopropyl carbazole that exhibits antidepressant and neuroprotective activities. -
glucokinase activator
PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4 ?μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus. -
Glucokinase activator
Piragliatin is a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus -
Glucokinase activator
Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM. -
Bcl-2 Family activator
(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. -
GLUT4 translocation activator
GLUT4 activator 1 (Compound 26b) is a potent glucose transporter type 4 (GLUT4) translocation activator with an EC50 of 0.14 μM. -
Calpain activator
Isovalerylcarnitine is a product of the catabolism of L-leucine. It increases calpain activity. -
NAMPT activator
SBI-797812 is a novel NAMPT activator, elevating liver NAD+, turning NAMPT into a "super catalyst" that more efficiently generates NMN. -
TrkB receptor activator
N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor. -
aryl hydrocarbon receptor activator
1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR). -
plasminogen activator inhibitor
TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 μM.- Yapeng Hou, .et al. , Am J Physiol Lung Cell Mol Physiol, 2022, 1;323(5):L569-L577 PMID: 36193902
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AhR activator
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent. -
Wnt/β-catenin activator
Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite. -
GK activator
Ro 28-1675 (Ro 0281675) is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM.
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dual α/γ PPAR activator
Peliglitazar racemate is the racemate of Peliglitazar. Peliglitazar is a novel dual α/γ PPAR activator. -
signal transducing G proteins activator
5'-GTP trisodium salt hydrate is an activator of the signal transducing G proteins and also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. -
GK activator
Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
