Oxidative Phosphorylation (OXPHOS)

Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and pancreatic ??-cells to uniquely target the key defects of type 2 diabetes.

Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity.

IMT1 is a first-in-class, specific, and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT). It induces a conformational change in POLRMT, preventing substrate binding and inhibiting transcription in a dose-dependent manner in vitro. IMT1 decreases deoxynucleoside triphosphate levels and citric acid cycle intermediates, leading to significant depletion of cellular amino acid levels. IMT1 holds potential for the treatment of diseases associated with mitochondrial transcription disorders.

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity.

IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).

Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor.

Acetomenaphthone is synthetic vitamin K which is also known as vitmin K4

Rafoxanide is a salicylanilide used as an anthelmintic. It is used to treat fluke, hookworm and other infestations.

Imeglimin is an oxidative phosphorylation blocker that acts to inhibit hepatic gluconeogenesis, increase muscle glucose uptake, and restore normal insulin secretion.

FCCP is an ionophore that is a mobile ion carrier. It is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

Oxyclozanide is a salicylanilide anthelmintic that is a proton ionophore which uncouples oxidative phosphorylation of the target organism.

IACS-010759 Hydrochloride is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).

VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS).