Catalog No.
Product Name
Application
Product Information
Citations
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RAR Antagonist
AGN 193109 sodium is a potent pan antagonist of retinoic acid receptors (RAR), specifically targeting RARα, RARβ, and RARγ with dissociation constants (Kd) of 2, 2, and 3 nM, respectively. This compound effectively reverses morphology changes induced by TTNPB and alleviates the proliferation suppression caused by all-trans retinoic acid, 9-cis RA, and 13-cis RA in ECE16-1 cells. Additionally, AGN 193109 sodium serves as an antidote for retinoic acidosis, mitigating skin and mucosal toxicity associated with retinoid treatment. -
Nurr1-RXRα Activator
BRF110 is a selective, orally active rexinoid that targets the Nurr1-Retinoid X Receptor alpha (RXRα) heterodimer, exhibiting an EC50 of 0.9 μM in SH-SY5Y cells. This compound upregulates brain-derived neurotrophic factor (BDNF) expression and demonstrates neuroprotective effects against MPP+-induced toxicity. Notably, BRF110 is capable of crossing the blood-brain barrier, making it a valuable tool for research in neurobiology and potential therapeutic applications in neurodegenerative diseases. -
RXR Modulator
LG101506 is a selective and orally active retinoid X receptor (RXR) modulator that exhibits a Ki of 2.7 nM for RXRα. This compound has demonstrated potential in research applications related to type 2 diabetes and cancer, making it a valuable tool for studying RXR's role in metabolic and oncological pathways. -
Retinoid Agonist
ER-38925 is a selective retinoid agonist targeting retinoic acid receptor subtype α (RAR-α). This compound demonstrates a dose-dependent ability to prolong the lifespan of recipient mice and effectively inhibits alloantigen-stimulated donor T lymphocyte proliferation in vitro. Additionally, ER-38925 can prevent the development of antiallogeneic cytotoxic T lymphocyte responses and suppress serum anti-DNA autoantibody production in mouse models of human chronic graft-versus-host disease (GVHD). Its unique properties make it a valuable tool for research in immunological responses and therapy development. -
Retinoic Acid Receptor Antagonist
LE-540 is a selective antagonist of the retinoic acid receptor beta (RARβ), with a reported inhibition constant (Ki) of 0.22 μM. This compound demonstrates significant potential in cancer research, specifically in the study of breast cancer and lung cancer. Through its ability to modulate RARβ activity, LE-540 can provide valuable insights into retinoid signaling pathways and their implications in tumorigenesis. -
RAR/RXR Agonist
5,6-Epoxyretinoic acid acts as an agonist for all isoforms of retinoic acid receptors (RAR), demonstrating EC50 values of 77 nM, 35 nM, and 4 nM for RARα, RARβ, and RARγ, respectively. This compound exhibits notable growth arrest in MCF-7 and NB4 cell lines at a concentration of 1 μM. As a natural metabolite of all-trans retinoic acid, which derives from vitamin A, 5,6-epoxyretinoic acid plays a significant role in various cellular processes and research applications related to cancer biology and retinoid signaling pathways. -
RAR/RXR Activator
TBTC is a selective retinoic acid receptor (RAR) and retinoid X receptor (RXR) activator. It demonstrates notable effects in improving behavioral deficits in Alzheimer's disease model mice, enhancing the activation of heterodimers formed by RXRα with LXRα or PPARγ. TBTC promotes the expression of key genes including apoE, ABCA1, and ABCG1, while effectively reducing amyloid-beta (Aβ) levels in cellular and animal studies, making it a valuable tool for Alzheimer’s research. -
RARγ Activator
NRX-204647 is a selective retinoic acid receptor gamma (RARγ) activator that exhibits high specificity compared to RARα and RARβ. This compound demonstrates significant biological activity in inhibiting bone formation, as evidenced by its ability to reduce bone volume/tissue volume (BV/TV). NRX-204647 is a valuable tool for investigating mechanisms in anti-cancer research and elucidating the role of RARγ in various biological processes. -
RXR/RAR Agonist
AGN-191659 is a potent agonist of retinoid X receptors (RXR) and retinoic acid receptors (RAR), exhibiting EC50 values of 11 nM, 23 nM, and 37 nM for RXRα, RARβ, and RARγ, respectively. It enhances gene transcription through activation of these receptors and has demonstrated significant biological activities, including the induction of tissue transglutaminase and suppression of chondrogenesis. Additionally, AGN-191659 effectively reverses fibroblast growth factor-induced endothelial cell proliferation and inhibits heparin-releasable lipase activity. This compound is valuable for research related to promyelocytic leukemia and hypertriglyceridemia. -
RARβ Agonist
BMS-948 is a selective agonist of the retinoic acid receptor beta (RARβ), exhibiting an EC50 of 0.1 µM. This compound plays a significant role in the modulation of gene expression related to tumor progression, embryonic development, and tissue remodeling. It serves as a valuable tool for investigating the biological functions of RARβ in various research applications. -
RXRα Agonist
GW0791 is an RXRα agonist with an EC50 of 5 nM. This compound demonstrates significant biological activity in modulating retinoid signaling pathways, making it a valuable tool for cancer research. Its ability to activate RXRα offers potential insights into mechanisms of tumorigenesis and opportunities for therapeutic development. -
RXR Agonist
(all-E)-UAB30 is a selective agonist of the retinoid X receptor (RXR). It demonstrates significant anti-proliferative activity in MyLa, HuT 78, and HH cell lines, with IC50 values of 34.7 μM, 5.1 μM, and 22.4 μM, respectively. This compound is valuable for research focused on cancer biology and RXR signaling pathways, providing insights into cell growth regulation. -
RARγ Activator
BMS-185354 is a selective retinoic acid receptor gamma (RARγ) activator, exhibiting an EC50 value of 28 nM. This compound plays a significant role in modulating gene expression involved in various biological processes. BMS-185354 is primarily utilized in cancer research to investigate the therapeutic potential of targeting RARγ pathways in oncogenesis and tumor progression. -
RAR/RXR Inhibitor
AGN 191701 is a selective retinoic acid receptor (RAR) and retinoid X receptor (RXR) inhibitor. This compound has been shown to induce liver enlargement in rat models while preserving hepatocellular integrity, indicating a unique biological profile. AGN 191701 serves as a valuable tool for studying retinoid signaling pathways and their implications in hepatic processes. -
Nurr1/RXR Dual Agonist
Nurr1/RXR Agonist 1 is a dual agonist that specifically targets the Nurr1 receptor (EC50 = 2.6 µM) and retinoid X receptor (RXR) with affinity constants of 0.6 and 1.1 µM, respectively. This compound selectively activates the DR5 response element by destabilizing the Nurr1 homodimer while stabilizing the Nurr1:RXR heterodimer. Nurr1/RXR Agonist 1 promotes the expression of neuroprotective target genes while minimizing off-target effects in neuronal cells. This reagent is suitable for research in neurodegenerative diseases. -
RARA/RARB/RARG Agonist
JP3000 is a potent agonist of retinoic acid receptors RARA, RARB, and RARG. This compound is designed to modulate gene expression involved in cellular differentiation, development, and homeostasis. Its applications in research include investigating the molecular mechanisms of retinoid signaling in various biological processes and disease states, making it a valuable tool for exploring therapeutic strategies in cancer and metabolic disorders. -
RAR/RXR
AGN 190727 is a structural isomer of AGN 190121 and serves as an antagonist of the retinoic acid receptors (RAR) and retinoid X receptors (RXR). Unlike its counterpart AGN 190121, AGN 190727 does not activate RAR/RXR pathways. This compound is relevant for research exploring RAR/RXR signaling modulation and investigating the physiological effects of receptor antagonism, particularly in studies related to dyslipidemia and metabolic disorders. -
RXRα Antagonist
(E)-XS-060 is a selective RXRα antagonist that disrupts the interaction between pRXRα and PLK1. This compound induces RXRα-dependent mitotic arrest, thereby inhibiting cell proliferation. Its notable antitumor activity has been demonstrated in various cancer models, including breast cancer, lung adenocarcinoma, and liver cancer, making it a valuable tool for cancer research and therapeutic development. -
Fluorescent RXR Agonist
CU-6PMN is a fluorescent retinoid X receptor (RXR) agonist that selectively activates human RXRα with an EC50 value of 22 nM and a Ki value of 230 nM. This compound exhibits a maximum absorption wavelength of 396 nm and an emission wavelength of 453 nm when dissolved in 0.1 N NaOH aqueous solution. CU-6PMN is valuable for research applications involving RXR ligand screening and provides a useful tool for studying RXR-mediated biological processes. -
RARα Antagonist
BMS-185411 is a selective antagonist of the retinoic acid receptor alpha (RARα), exhibiting an IC50 value of 140 nM. This compound is instrumental in research focusing on the modulation of retinoic acid signaling pathways, particularly in the context of cellular differentiation, development, and cancer biology. Its ability to inhibit RARα activity makes it valuable for studies investigating the role of retinoic acid receptors in various biological processes. -
RAR Agonist
Seletinoid G is a potent retinoic acid receptor (RAR) agonist. It demonstrates significant biological activity by promoting the repair of altered connective tissue in aged skin while inhibiting UV-induced collagen deficiency in younger skin. This compound is valuable for research applications focused on skin aging and photoaging, facilitating the exploration of therapeutic strategies for improving skin health and resilience. -
angiotensin-converting enzyme Inhibitor, renin Inhibitor
Lyciumin D functions as both an angiotensin-converting enzyme inhibitor and a renin inhibitor. This compound demonstrates significant potential in the modulation of the renin-angiotensin system, making it a valuable tool for research into hypertension and related cardiovascular conditions. Its multimodal mechanism can facilitate studies aimed at understanding blood pressure regulation and developing therapeutic strategies for hypertension management. -
PROTAC Linkers
Boc-C1-PEG3-C4-OBn is a versatile PROTAC linker that incorporates a polyethylene glycol (PEG) structure. This compound facilitates the synthesis of various PROTACs, including the SGK3 degrader-1. By connecting ligands for E3 ubiquitin ligases and target proteins, Boc-C1-PEG3-C4-OBn is instrumental in harnessing the ubiquitin-proteasome system for the selective degradation of target proteins, providing valuable insights for protein regulation studies and therapeutic applications. -
Ser/Thr Protease
A-953227 is a highly selective inhibitor targeting serine/threonine proteases, specifically acting on calcium-dependent esterases such as calpain. This compound demonstrates strong inhibitory activity against related cysteine proteases, including cathepsins, showing considerable efficacy in cellular models. Preclinical studies indicate its potential as a therapeutic agent in Alzheimer's disease, highlighting its role in neurodegenerative research applications. -
Cathepsin D Substrate
Bz-RGFFP-4MβNA is a specific substrate for Cathepsin D, designed for use in either colorimetric or fluorometric assays. It enables the detection and quantification of Cathepsin D activity, making it a valuable tool for studying proteolytic processes and their implications in various biological conditions. This compound facilitates research in areas including cancer, neurodegenerative diseases, and other pathologies where Cathepsin D plays a critical role. -
Substrate Peptide Of Cathepsin S
Ac-KQKLR-AMC is a substrate peptide designed for the fluorescent monitoring of Cathepsin S activity. Labeled with AMC, this compound exhibits excitation and emission wavelengths of 354 nm and 442 nm, respectively. It is primarily utilized in biochemical assays to measure the enzymatic activity of Cathepsin S, providing valuable insights into its role in physiological and pathological processes. -
Serine Protease Inhibitor
VD5123 is a potent serine protease inhibitor that effectively targets TMPRSS2, HGFA, matriptase, and hepsin, exhibiting IC50 values of 15 nM, 3980 nM, 140 nM, and 37 nM, respectively. This compound is particularly useful for antiviral research, including studies focused on SARS-CoV-2 and a broad spectrum of coronaviruses, as well as influenza viruses. Its ability to inhibit key proteases makes VD5123 an important tool in the investigation of viral pathogenesis and therapeutic development. -
Ser/Thr Protease Inhibitor
Nacresertib is a selective Ser/Thr protease inhibitor that targets specific proteolytic pathways within cells. This compound is pivotal in studying cellular signaling mechanisms and apoptosis, making it valuable for research focused on cancer and neurodegenerative diseases. Its ability to modulate protease activity allows for the exploration of therapeutic strategies in various pathological states. -
Insect Sex Pheromone
Bombykol is an insect sex pheromone primarily known for its role in sexual attraction among Bombyx mandarina females. This compound serves as a potent attractant for male moths, facilitating mating behaviors. Bombykol is utilized in research applications related to entomology, behavior studies, and pest control strategies, providing insights into insect communication and reproduction. -
Insect Pheromone
(Z)-11-Octadecenal is a key insect pheromone that plays a significant role in the communication of female rice leaffolder moths. This compound demonstrates diurnal stability, making it a valuable reagent for studies on pest behavior and ecology. It is often utilized in research applications focused on insect attractants, pheromone signaling, and the development of sustainable pest management strategies. -
Sex Pheromone
Lavandulyl senecioate is a senecioyl ester of lavandulol, functioning as a sex pheromone. The (S)-enantiomer of this compound is known to play a crucial role in the mating behavior of the vine mealybug (Planococcus ficus). This pheromone can be utilized in research applications related to pest management and behavioral ecology studies. -
Volatile Component
3-Methyltridecane is a volatile organic compound primarily identified as a secretion from the metathoracic scent gland in Tessaratoma papillosa. This compound plays a significant role in chemical communication, serving as a defensive allogen, alarm pheromone, and aggregation pheromone. Its volatility makes it relevant for studies on insect behavior and ecological interactions, providing insights into pheromonal communication systems. -
1-benzoyl-β-d-glucose
Periplanetin is a peptide derived from the insect lipomotor hormone family, specifically the AKH family, isolated from the cervical organ of Periplaneta americana and Blatta orientalis. This compound exhibits potential analgesic properties and has been shown to lower the threshold for tonic seizures. Periplanetin can be utilized in research focusing on pain modulation and seizure activity, providing insights into the neurobiological mechanisms underlying these conditions. -
Insect Pheromone
(E,E)-10,12-Hexadecadienal is an insect pheromone that plays a crucial role in the mating behavior of various moth species, particularly isolated from female Earias insulana. This compound is important for studying chemical communication in insects and can be utilized in research focused on pest management and behavior modulation. Its applications extend to the development of traps and lures for effective monitoring and control of agricultural pests. -
Insect Pheromone
(±)-Ipsdienol is an insect pheromone that serves as a sex attractant for male spruce beetles (Dendroctonus rufipennis). This compound is isolated from subspecies of spruce beetles (Ips tridens) and is utilized in research to study insect behavior and ecology. Its application is pivotal in understanding pest dynamics and developing management strategies in forestry. -
Insect Pheromone
Gossyplure is an insect pheromone designed to attract and capture male pink bollworm moths and corn earworms. Its primary mechanism involves mimicking the natural pheromones released by females, effectively disrupting mating patterns and reducing pest populations. Gossyplure finds applications in agricultural research and pest management strategies aimed at controlling these destructive insects, thereby safeguarding crop yield and quality. -
Pheromone in Moth
Disparlure is a sex pheromone that targets specific receptors in moths, playing a crucial role in mating behavior. This compound is widely used in entomological research to study moth communication and behavior. Disparlure serves as an essential tool in ecological studies and pest management applications by disrupting mating patterns in various moth species. -
Antiaggregative Pheromone
3-Methylcyclohex-2-en-1-ol acts as a potent antiaggregative pheromone, isolated from the bark beetle Dendroctonus. This compound significantly influences insect behavior by disrupting aggregation processes, making it valuable in entomological research and pest management studies. Its application extends to investigations on pest control strategies and ecological interactions among species. -
Bait For Male Moths
(Z,Z)-3,13-Octadecadienyl acetate is a pheromone compound that primarily targets male moths for attraction. Isolated from the pheromone gland extracts of female S. bicingulata moths, this compound plays a crucial role in the sexual signaling of the species. It serves as an effective bait for the trapping and study of male moths, facilitating research in entomology and pest management. -
Sex Pheromone Inhibitor
iPD1 is a potent inhibitor of the sex pheromone cPD1, targeting pheromone signaling pathways. This compound effectively blocks the biological activity of sex pheromones, making it valuable in studies related to behavioral ecology and reproductive biology. Its application in research can provide insights into pheromone-mediated communication and its ecological impacts. -
sex pheromone
1,7-Dioxaspiro[5.5]undecane is identified as a sex pheromone in fruit flies, playing a crucial role in mating behavior. This compound is pivotal for studies focusing on insect communication and reproductive biology. Its applications extend to research involving behavioral assays and the understanding of pheromone signaling pathways in insects. -
Insect Pheromone
Ethyl (E,Z)-2,4-decadienoate acts as an insect pheromone, specifically targeting male cold moths by inducing an electroshock response in their Sensilla Auricillica. This compound can be isolated from host plants and plays a crucial role in the study of insect behavior and communication. Its applications extend to research in entomology and pest management strategies. -
Insect Pheromone
(E,Z)-4,7-Tridecadienyl acetate is a sex pheromone primarily associated with the potato tuber moth (Phthorimaea opercucella). This compound plays a crucial role in mediating communication and mating behavior among insects. Its applications extend to entomological research, particularly in studies focused on pest management and behavioral ecology. -
Insect Pheromone
(Z)-13-Octadecen-1-ol is an insect sex pheromone that serves as a target compound for the management of agricultural pests, specifically for trapping sugarcane stem borers (Chilo sacchariphagus). This compound facilitates the study of pest behavior and can be instrumental in the development of environmentally sustainable pest control strategies. Its application in research enhances the understanding of insect communication and can lead to improved agricultural practices. -
Insect Pheromone
(3E,8Z)-3,8-Tetradecadienyl acetate functions as an insect sex pheromone, primarily associated with the attraction of male South American potato tuber moths (Scrobipalpula absoluta) to unmated females. This compound is widely utilized in entomological research and pest management studies to better understand mating behaviors and develop effective strategies for monitoring and controlling pest populations. Its role as a pheromone makes it valuable for investigating communication mechanisms among insects and contributes to the advancement of environmentally friendly pest control methods. -
Insect Pheromone
Decyl acetate is a synthetic compound acting as an insect pheromone, specifically targeting male false codling moths (Cryptophlebia leucotreta). It is utilized in research related to pest control and insect behavior studies, leveraging its ability to attract male moths for monitoring and trapping purposes. This compound contributes to the understanding of insect communication and can aid in developing eco-friendly pest management strategies. -
EAG Stimulant
(Z)-9-Dodecenyl acetate is a monounsaturated dodecenyl acetate that acts as an EAG stimulant. It induces electroantennogram (EAG) responses in the antennae of male Choristoneura rosaceana, making it a valuable tool for research on insect olfactory responses and behavior. This compound is applicable in studies focused on pheromone signaling and attraction inhibition in ecological and agricultural contexts. -
Sex Attractant
(13Z)-Eicosen-10-one functions as a sex attractant, primarily targeting carposina coreana. This compound plays a significant role in facilitating mating behaviors in these insects. It is valuable for research applications focused on insect behavior, pheromone studies, and pest management strategies. -
Insect Pheromone
(2E,13Z)-Octadecadienyl acetate is an insect sex pheromone that specifically attracts clearwing moths (Synanthedon tipuliformis) and raspberry crown borers (Pennisetia marginata). This compound elicits significant olfactory responses in male insects, making it valuable for research in pest control and behavior studies. Its application in entomology can aid in developing targeted strategies for managing pest populations. -
Sex Pheromone
(4Z)-4-Nonenal is a sex pheromone derived from the Male Tropical West African Shield Bug, Sphaerocoris annulus. This compound plays a crucial role in facilitating communication and mating behaviors within this species. Its unique chemical properties make it a valuable tool for studying pheromonal signaling and insect behavior in ecological and chemical research applications.
