• Sign In
  • FAQ
  • Create an Account
Currency
USD currency flagUSD
Toggle Nav
My Cart
Menu
Account
Settings
Currency
USD currency flagUSD

Metabolism

Shop By
Clear All

Items 1-50 of 2992

Page
per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Citations
  1. A10707
    Pemetrexed disodium (Alimta)

    DHFR inhibitor

    Pemetrexed disodium is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis?€?thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.
    Quick View
  2. A10435
    Gossypol

    dehydrogenase inhibitor

    Gossypol is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
    Quick View
  3. A14339
    U 73122

    Phospholipase C inhibitor

    U 73122 is a phospholipase C inhibitor. It inhibits agonist-induced platelet aggregation with IC50 values of 1-5 uM.
    Quick View
  4. A13343
    Zinc Protoporphyrin

    HO-1 inhibitor

    Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2.
    Quick View
  5. A10804
    Roflumilast

    PDE inhibitor

    Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4.
    Quick View
  6. A11062
    Onalespib (AT13387)

    HSP90 Inhibitor

    AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.
    Quick View
  7. A13247
    Ferrostatin-1 (Fer-1)

    ferroptosis inhibitor

    Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.
    Quick View
  8. A15554
    Epacadostat (INCB024360)

    IDO inhibitor

    Epacadostat is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM, Phase 2,
    Quick View
  9. A11928
    LCL-161

    Antagonist of IAPs inhibitor

    LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.
    Quick View
  10. A17323
    Valproic acid

    HDAC inhibitor

    Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
    Quick View
  11. A14317
    Edoxaban (tosylate Monohydrate)

    Factor Xa inhibitor

    Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM
    Quick View
  12. A10082
    Apixaban (BMS-562247-01)

    Factor Xa inhibitor

    Apixaban is an anticoagulant for the prevention of venous thromboembolism and venous thromboembolic events.
    Quick View
  13. A10741
    (E/Z)-Polydatin ((E/Z)-Piceid)

    PLA inhibitor

    Polydatin protects cerebral cells from ischemic damages via improvement of microcirculation and inhibition of platelet aggregation. In addition, polydatin inhibits ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide; it also attenuates adhesion between white blood cells and endothelial cells.
    Quick View
  14. A18420
    IDH1 Inhibitor 2

    IDH1 inhibitor

    DH1 Inhibitor 2 is a potent IDH1 inhibitor via a direct covalent modification of His315, with an IC50 of 110 nM.
    Quick View
  15. A11402
    Ganetespib (STA-9090)

    Hsp90 inhibitor

    Ganetespib is a potent, synthetic, small molecule inhibitor of Hsp90, a chaperone protein that is essential to the function of certain other proteins that drive the growth, proliferation, and survival of many different types of cancer.
    Quick View
  16. A14325
    LP-533401

    Tph1 inhibitor

    LP-533401 is a small molecule inhibitor of Tph1.
    Quick View
  17. A15865
    RSL3

    Ferroptosis inhibitor

    RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.
    Quick View
  18. A12769
    Zofenopril calcium

    ACE inhibitor

    Zofenopril calcium is an angiotensin-converting enzyme ACE inhibitor.
    Quick View
  19. A13309
    GSK-650394

    SGK1 inhibitor

    GSK 650394 is a glucocorticoid- and serum-regulated kinase 1 (SGK1) inhibitor which displays antiproliferative properties against the LNCaP prostate carcinoma cell line.
    Quick View
  20. A12105
    Punicalagin

    Carbonic anhydrase inhibitor

    Punicalagin is an ellagitannin, a type of phenolic compounds. It is a highly active carbonic anhydrase inhibitor.
    Quick View
  21. A10454
    Hordenine

    MAO-B inhibitor

    Hordenine is a phenethylamine alkaloid with antibacterial and antibiotic properties.
    Quick View
  22. A10216
    Cilomilast (SB-207499)

    PDE-4 inhibitor

    Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD.
    Quick View
  23. A11019
    Ibudilast (KC-404)

    PDE Inhibitor

    Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells.
    Quick View
  24. A13502
    Z-FL-COCHO (LY3000328)

    Cathepsin S inhibitor

    Z-FL-COCHO (LY3000328) is a novel Cathepsin S inhibitor.

     
    Quick View
  25. A11768
    Radicicol

    Hsp90/SRC/COX-2 Inhibitor

    Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2
    Quick View
  26. A18874
    HSP27 inhibitor J2

    HSP27 inhibitor

    HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof.
    Quick View
  27. A11074
    PF-04929113 (SNX-5422)

    Hsp90 inhibitor

    PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.
    Quick View
  28. A13998
    DMOG

    HIF-PH inhibitor

    DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM.
    Quick View
  29. A11195
    KW-2478

    HSP90 inhibitor

    KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.

    Quick View
  30. A10660
    NVP-BEP800

    HSP90 Inhibitor

    NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH2-terminal ATP-binding pocket of Hsp90.
    Quick View
  31. A13743
    Atorvastatin

    HMG-CoA reductase inhibitor

    Atorvastatin is an HMG-CoA reductase inhibitor (IC50 = 154 nM) that is effective in treating hypercholesterolemia and certain dyslipidemias.
    Quick View
  32. A10396
    Fludarabine (Fludara)

    STAT inhibitor

    Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells.
    Quick View
  33. A10225
    Clarithromycin

    cytochrome P4503A4 inhibitor

    Clarithromycin is a macrolide antibiotic. It prevents bacteria from growing by interfering with their protein synthesis.
    Quick View
  34. A11397
    Evacetrapib (LY2484595)

    CETP inhibitor

    Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3.
    Quick View
  35. A11172
    Nepicastat HCl

    DBH inhibitor

    Nepicastat hydrochloride is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

    Quick View
  36. A10292
    Decitabine

    DNA Methyltransferase Inhibitors

    Decitabine is a hypomethylating agent.It hypomethylates DNA by inhibiting DNA methyltransferase.
    Quick View
  37. A11230
    PF 429242

    SREBP inhibitor

    PF 429242 is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease.
    Quick View
  38. A15871
    AS1842856

    Foxo1 Inhibitor

    AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form.
    Quick View
  39. A10889
    Tanshinone I

    Phospholipase inhibitor

    Tanshinones are the major bioactive compounds of Salvia miltiorrhiza Bunge (Danshen) roots, which are used in many therapeutic remedies in Chinese traditional medicine.
    Quick View
  40. A12390
    JZL195

    dual FAAH/MAGL inhibitor

    JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.
    Quick View
  41. A11049
    URB597

    FAAH inhibitor

    URB597 is a relatively selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH).
    Quick View
  42. A12747
    JZL184

    MAGL Inhibitor

    JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).
    Quick View
  43. A21069
    VBY-825

    cathepsin inhibitor

    VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.
    Quick View
  44. A10020
    Abiraterone (CB-7598)

    CYP17 inhibitor

    Abiraterone (CB-7598) inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1), an enzyme which is expressed in testicular, adrenal, and prostatic tumor tissues.

    Quick View
  45. A11534
    Pentostatin

    Adenosine deaminase inhibitor

    Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM).
    Quick View
  46. A10659
    AUY922 (Luminespib, NVP-AUY922)

    HSP90 Inhibitor

    AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
    Quick View
  47. A13351
    VER 155008

    HSP 70 inhibitor

    VER 155008 is a small molecule, ATP-derivative inhibitor of HSP70 (IC50 = 500 nM).
    Quick View
  48. A11885
    Moclobemide

    MAO Inhibitor

    Moclobemide is a reversible and selective inhibitor of monoamine oxidase A (MAO-A).
    Quick View
  49. A16205
    WNK463

    pan-WNK-kinase inhibitor

    WNK463 is an orally bioavailable pan-WNK-kinase inhibitor.
    Quick View
  50. A10676
    Orlistat

    FASN inhibitor

    Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice.  Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity. Anti-atherosclerotic effect. 

    Quick View

Items 1-50 of 2992

Page
per page
Set Descending Direction
Shop By
Now Shopping by
  1. Actions
    Inhibitor
Clear All
Shopping Options
Category
Target
  1. STK 3items
  2. WNK 2items
  3. GCN 2items
  4. GAK 1item
  5. SRPK 3items
  6. PASK 1item
  7. BUB1 4items
  8. Tyk2 1item