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DNA/RNA Synthesis

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Items 1-50 of 57

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  1. A10036
    Cycloheximide (Actidione)

    Protein Synthesis Inhibitor

    Cycloheximide (also known as actidione) is used as an selective antibiotic. It inhibits the protein synthesis (DNA-dependent RNA) of saprobic fungi eukaryotes. by binding with the 80S ribosome, while inactive against dermatophytes and systemic fungi.
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  2. A10042
    Fluorouracil (Adrucil)

    DNA and RNA synthesis inhibitor

    Fluorouracil (Adrucil) is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase.
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  3. A10152
    Bleomycin sulfate

    DNA/RNA Synthesis inhibitor

    Bleomycin sulfate is a mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus.
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  4. A10214
    Cidofovir (Vistide)

    DNA/RNA Synthesis inhibitor

    Cidofovir (Vistide) is an antiviral used for the treatment of cytomegalovirus (CMV) infection (ie: retinitis).
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  5. A10228
    Clofarabine

    DNA/RNA Synthesis inhibitor

    Clofarabine is a second generation purine nucleoside analog with antineoplastic activity
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  6. A10289
    Daptomycin

    DNA/RNA Synthesis inhibitor

    Daptomycin is a lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms.
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  7. A10346
    Oxaliplatin (Eloxatin)

    DNA/RNA Synthesis inhibitor

    Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. In vivo studies showed that Oxaliplatin has anti-tumor activity against colon carcinoma through its (non-targeted) cytotoxic effects.
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  8. A10392
    Floxuridine

    DNA/RNA Synthesis inhibitor

    Floxuridine is an oncology drug that belongs to the class known as antimetabolites.
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  9. A10407
    Tegafur

    DNA/RNA Synthesis inhibitor

    Tegafur is a chemotherapeutic 5-FU prodrug used in the treatment of cancers. It is a component of tegafur-uracil.
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  10. A10423
    Gemcitabine HCl (Gemzar)

    DNA/RNA Synthesis inhibitor

    Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.
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  11. A10776
    Raltitrexed (Tomudex)

    DNA/RNA Synthesis inhibitor

    Raltitrexed (Tomudex) is an inhibitor of thymidylate synthase and also is one of the strongest antimetabolites in use.
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  12. A11065
    CX-5461

    DNA/RNA Synthesis inhibitor

    CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively

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  13. A11147
    CCT239065

    DNA, RNA Synthesis Inhibitor

    CCT239065 is a mutant protein kinase inhibitor that inhibits signaling downstream of V600EBRAF in cancer cells, blocking DNA synthesis, and inhibiting proliferation.
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  14. A11179
    NSC-207895 (XI-006)

    MDMX Inhibitor

    NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

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  15. A11434
    Gemcitabine

    DNA synthesis inhibitor

    Gemcitabine (LY 188011) is a DNA synthesis inhibitor which inhibits the growth of BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells with IC50s of 37.6, 42.9, 92.7, 89.3 and 131.4 nM, respectively.
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  16. A11491
    Mitomycin C

    DNA synthesis inhibitor

    Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells.
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  17. A11612
    YK 4-279

    RHA inhibitor

    YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1.
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  18. A12337
    4E2RCat

    eIF4E-eIF4G interaction inhibitor

    4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
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  19. A12409
    Epirubicin

    Topoisomerase inhibitor

    Epirubicin is a cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin that exhibits reduced cardiotoxicity. Epirubicin?€?s antitumor actions are mediated by targeting and inhibiting Topo II (topoisomerase II).
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  20. A13260
    NSC16168

    ERCC1-XPF inhibitor

    NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC50 value of 0.42 μM. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer.
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  21. A13652
    AVN-944

    IMPDH inhibitor

    AVN-944 (also known as VX-944) serves as an effective oral inhibitor, specifically targeting and inhibiting IMPDH (inosine monophosphate dehydrogenase). This enzyme plays a crucial role as a rate-limiting factor in the synthesis of guanine nucleotides from scratch. Additionally, AVN-944 acts against the synthesis of RNA in arenaviruses, effectively preventing arenavirus infections. Demonstrating a wide spectrum of anti-cancer properties, AVN-944 is utilized in research related to multiple myeloma (MM) and acute myeloid leukemia (AML).

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  22. A14199
    4EGI-1

    eIF4E/eIF4G inhibitor

    4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 uM.
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  23. A14230
    Mupirocin

    isoleucyl t-RNA synthetase inhibitor

    Mupirocin is an isoleucyl t-RNA synthetase inhibitor.
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  24. A14252
    Chloroambucil

    DNA/RNA Synthesis inhibitor

    Chlorambucil is a nitrogen mustard alkylating agent.
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  25. A14268
    Puromycin 2HCl

    protein synthesis inhibitor

    Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.
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  26. A14301
    4E1RCat

    eIF4F subunit interaction inhibitor

    4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction.
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  27. A14304
    CRT0044876

    APE1 inhibitor

    CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
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  28. A14440
    E3330

    APE1 Redox Inhibitor

    E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
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  29. A15447
    SCR7

    DNA ligase IV inhibitor

    SCR7 is a specific DNA Ligase IV inhibitor. SCR7 inhibits end joining of double strand breaks in diverse cell types resulting in tumour regression by activation of p53 mediated apoptosis.
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  30. A15790
    L189

    DNA Ligase Inhibitor

    L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.
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  31. A15898
    6-Mercaptopurine Monohydrate

    de novo purine synthesis inhibitor

    6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
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  32. A15978
    L67

    DNA ligases inhibitor

    L67 is a DNA Ligase Inhibitor. L67 inhibited DNA ligases I and III. L67 is a simple competitive inhibitor with respect to nicked DNA.
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  33. A16194
    RK-33

    DDX3 inhibitor

    RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity.
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  34. A16203
    AN2718

    RNA synthetase inhibitor

    AN2718 is a novel boron-containing small molecule that inhibits an essential protein synthesis enzyme, leucyl-transfer RNA synthetase, or LeuRS.
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  35. A16355
    CeMMEC13

    TAF1 inhibitor

    CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).
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  36. A17138
    SCR7 pyrazine

    NHEJ inhibitor

    SCR7 pyrazine is an inhibitor of nonhomologous end-joining (NHEJ).
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  37. A17215
    Tetrahydrouridine

    Cytidine deaminase Inhibitor

    Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively).
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  38. A18601
    Pyrazofurin

    OPRTase inhibitor

    Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5'-phosphate (UMP) synthase[1]. Pyrazofurin is an active, sensitive orotate-phosphoribosyltransferase inhibitor with IC50s between 0.06-0.37 ?M in the three squamous cell carcinoma (SCC) cell lines Hep-2, HNSCC-14B and HNSCC-14C.
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  39. A18729
    AOH1160

    PCNA inhibitor

    AOH1160 is a potent, first-in-class, orally available small molecule proliferating cell nuclear antigen (PCNA) inhibitor, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, causes cell-cycle arrest and induces apoptosis.
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  40. A18795
    Metarrestin

    PNC inhibitor

    Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis.
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  41. A18935
    PTC299

    VEGFA inhibitor

    PTC299 is a potent, orally bioavailable VEGFA inhibitor, targets dihydroorotate dehydrogenase (DHODH), resulting in cell growth inhibition and differentiation in leukemias, including acute myeloid leukemia, linking DHODH regulation and stress-induced VEGFA and angiogenesis.
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  42. A19000
    Xanthopterin

    DNA/RNA Synthesis inhibitor

    Xanthopterin is a yellow, crystalline solid that inhibits the growth of lymphocytes produced by concanavalin.
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  43. A19168
    JH-RE-06

    REV1-REV7 interface inhibitor

    JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ.
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  44. A19900
    CeMMEC1

    BRD4 inhibitor

    CeMMEC1 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC50 of 0.9 μM for TAF1, and a Kd of 1.8 μM for TAF1 .
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  45. A20271
    Asp-AMS

    aspartyl-tRNA synthetase inhibitor

    Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.
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  46. A20930
    Galidesivir hydrochloride

    RdRp inhibitor

    Galidesivir hydrochloride (BCX 4430 hydrochloride) is a viral RNA-dependent RNA polymerase (RdRp) inhibitor; demonstrated broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile.
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  47. A21056
    Thiarabine

    DNA synthesis inhibitor

    Thiarabine (OSI-7836) shows potent anti-tumor activity and inhibition of DNA synthesis.
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  48. A21392
    Filibuvir

    non-nucleoside inhibitor

    Filibuvir is a potent, selective non-nucleoside inhibitor (NNI) of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase, and it binds noncovalently in the ??Thumb 2?? pocket of NS5B.
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  49. A21427
    NITD008

    flaviviruse inhibitor

    NITD008 is a potent and selective flaviviruse inhibitor which can inhibit Dengue Virus Type 2 (DENV-2) with an EC50 of 0.64 μM.
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  50. A21653
    TH588 hydrochloride

    nudix hydrolase family inhibitor

    TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).
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