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$0.00 - Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
Biological Activity
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant. Its potency is about 20-30 times that of the naturally occurring hormone hydrocortisone and 4-5 times of prednisone.
| In vitro (25°C) | DMSO | 73 mg/mL (186 mM) | |
| Water | Insoluble | ||
| Ethanol | 6 mg/mL (15.28 mM) | ||
| In vivo | 5% DMSO+45% PEG 300+H2O | 12 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.48 mL | 127.39 mL | 254.78 mL |
| 0.5 mM | 5.1 mL | 25.48 mL | 50.96 mL |
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
*The above data is based on the productmolecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10299 |
|---|---|
| CAS No. | CAS: 50-02-2 |
| Formula | C22H29FO5 |
| M. Wt | 392.5 |
| Purity | >98% |
| Synonyms | Decadron |
| SMILES | C[[email protected]@H]1C[[email protected]]2[[email protected]@H]3CCC4=CC(=O)C=C[[email protected]@]4([[email protected]]3([[email protected]](C[[email protected]@]2([[email protected]]1(C(=O)CO)O)C)O)F)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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