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Dexamethasone

Catalog No.: A10299

Dexamethasone

Dexamethasone Chemical Structure

CAS NO. CAS: 50-02-2

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant. Its potency is about 20-30 times that of the naturally occurring hormone hydrocortisone and 4-5 times of prednisone.

Availability: In stock

Package Price Qty
500 mg
$45.00
10mM * 1mL in DMSO
$60.00
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  • Ken Kobayashi, .et al. Lactose on the basolateral side of mammary epithelial cells inhibits milk production concomitantly with signal transducer and activator of transcription 5 inactivation, Cell Tissue Res, 2022, Sep;389(3):501-515 PMID: 35748981
  • Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967

Biological Activity

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant. Its potency is about 20-30 times that of the naturally occurring hormone hydrocortisone and 4-5 times of prednisone.
In vitro (25°C) DMSO 73 mg/mL (186 mM)
Water Insoluble
Ethanol 6 mg/mL (15.28 mM)
In vivo 5% DMSO+45% PEG 300+H2O 12 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.48 mL 127.39 mL 254.78 mL
0.5 mM 5.1 mL 25.48 mL 50.96 mL
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL

*The above data is based on the productmolecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10299
CAS No. CAS: 50-02-2
Formula C22H29FO5
M. Wt 392.5
Purity >98%
Synonyms Decadron
SMILES C[[email protected]@H]1C[[email protected]]2[[email protected]@H]3CCC4=CC(=O)C=C[[email protected]@]4([[email protected]]3([[email protected]](C[[email protected]@]2([[email protected]]1(C(=O)CO)O)C)O)F)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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