Danoprevir (RG7227)

Name: Danoprevir (RG7227)
SKU: A10284

Catalog No.: A10284

HCV NS3/4A protease inhibitor

Product Citations (2)

Danoprevir (RG7227) Chemical Structure

CAS NO. 850876-88-9

Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.

Availability: In stock

Package	Price	Qty
2 mg	$60.00
5 mg	$120.00
10 mg	$200.00
50 mg	$600.00
10mM * 1mL in DMSO	$274.00

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

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Biological Activity

Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.

Targets

HCV NS3/4A protease
0.2 nM-3.5 nM

Solubility *

In vitro	DMSO	144 mg/mL (196.76 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	144 mg/mL (196.76 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.93 mL	69.65 mL	139.3 mL
0.5 mM	2.79 mL	13.93 mL	27.86 mL
1 mM	1.39 mL	6.96 mL	13.93 mL
5 mM	0.28 mL	1.39 mL	2.79 mL

*The above data is based on the productmolecular weight 717.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10284
Actions	Inhibitor
M. Wt	717.9
Formula	C35H48FN5O8S
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	850876-88-9
Synonyms	RG7227, ITMN-191, RO5190591
SMILES	CC(C)(C)OC(=O)N[[email protected]]1CCCCC/C=C/[[email protected]@H]2C[[email protected]]2(NC(=O)[[email protected]@H]3C[[email protected]](CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6