Danoprevir (RG7227)

Name: Danoprevir (RG7227)
Brand: Adooq Bioscience
SKU: A10284
Rating: 100 (2 reviews)

Catalog No.: A10284

HCV NS3/4A protease inhibitor

Product Citations (2)

Danoprevir (RG7227) Chemical Structure

CAS NO. 850876-88-9

Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.

Availability: In stock

Package	Price	Qty
2 mg	$60.00
5 mg	$120.00
10 mg	$200.00
50 mg	$600.00
10mM * 1mL in DMSO	$274.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Danoprevir (RG7227)

Inês GARCEZ PALHA, .et al. An in vivo translation-reporter system for the study of protein synthesis in zebrafish embryos, Biol Open, 2018, Nov 7 PMID: 30404898
Hui Shen, .et al. Inhibitory Effects of Caffeic Acid Phenethyl Ester Derivatives on Replication of Hepatitis C Virus, PLoS One., 2013, 8(12): e82299 PMID: 24358168

Biological Activity

Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.

Targets

HCV NS3/4A protease
0.2 nM-3.5 nM

Solubility *

In vitro	DMSO	124 mg/mL (169.43 mM)
	Water	Insoluble
	Ethanol	124 mg/mL (169.43 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.66 mL	68.32 mL	136.65 mL
0.5 mM	2.73 mL	13.66 mL	27.33 mL
1 mM	1.37 mL	6.83 mL	13.66 mL
5 mM	0.27 mL	1.37 mL	2.73 mL

*The above data is based on the productmolecular weight 731.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10284
Actions	Inhibitor
CAS No.	850876-88-9
Formula	C35H46FN5O9S
M. Wt	731.8
Purity	>98%
Synonyms	RG7227, ITMN-191, RO5190591
SMILES	CC(C)(C)OC(=O)N[[email protected]]1CCCCC/C=C\[[email protected]@H]2C[[email protected]]2(NC(=O)[[email protected]@H]3C[[email protected]](CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.