Danoprevir (RG7227)

Catalog No.: A10284

HCV NS3/4A protease inhibitor

Danoprevir (RG7227)

Danoprevir (RG7227) Chemical Structure

CAS NO. 850876-88-9

Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.

Availability: In stock

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2 mg
5 mg
10 mg
50 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Inês GARCEZ PALHA, .et al. An in vivo translation-reporter system for the study of protein synthesis in zebrafish embryos, Biol Open, 2018, Nov 7 PMID: 30404898
  • Hui Shen, .et al. Inhibitory Effects of Caffeic Acid Phenethyl Ester Derivatives on Replication of Hepatitis C Virus, PLoS One., 2013, 8(12): e82299 PMID: 24358168

Biological Activity

Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.
HCV NS3/4A protease
0.2 nM-3.5 nM
In vitro DMSO 144 mg/mL (196.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol 144 mg/mL (196.76 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.93 mL 69.65 mL 139.3 mL
0.5 mM 2.79 mL 13.93 mL 27.86 mL
1 mM 1.39 mL 6.96 mL 13.93 mL
5 mM 0.28 mL 1.39 mL 2.79 mL

*The above data is based on the productmolecular weight 717.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10284
Actions Inhibitor
M. Wt 717.9
Formula C35H48FN5O8S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 850876-88-9
Synonyms RG7227, ITMN-191, RO5190591
SMILES CC(C)(C)OC(=O)N[[email protected]]1CCCCC/C=C/[[email protected]@H]2C[[email protected]]2(NC(=O)[[email protected]@H]3C[[email protected]](CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6

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