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Danoprevir (RG7227)


HCV NS3/4A protease inhibitor

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Catalog No. A10284

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Danoprevir 2mg A10284-2

Regular Price: €57.00

Special Price: €51.30

Danoprevir 5mg A10284-5

Regular Price: €114.00

Special Price: €102.60

Danoprevir 10mg A10284-10

Regular Price: €190.00

Special Price: €171.00

Danoprevir 50mg A10284-50

Regular Price: €570.00

Special Price: €513.00

Danoprevir (RG7227) 10mM * 1mL in DMSO A10284-10mM-D

Regular Price: €260.30

Special Price: €234.27

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.

Danoprevir (RG7227)

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Publications citing Adooq Products
Danoprevir (RG7227) Citations (2)
  • Inês GARCEZ PALHA, .et al. An in vivo translation-reporter system for the study of protein synthesis in zebrafish embryos, Biol Open, 2018, Nov 7 PMID: 30404898
  • Hui Shen, .et al. Inhibitory Effects of Caffeic Acid Phenethyl Ester Derivatives on Replication of Hepatitis C Virus, PLoS One., 2013, 8(12): e82299 PMID: 24358168

Chemical Information

Catalog Num A10284
Actions Inhibitor
M. Wt 717.9
Formula C35H48FN5O8S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 850876-88-9
Synonyms RG7227, ITMN-191, RO5190591
SMILES CC(C)(C)OC(=O)N[[email protected]H]1CCCCC/C=C/[[email protected]@H]2C[[email protected]]2(NC(=O)[[email protected]@H]3C[[email protected]](CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6

Biological Activity

Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.
HCV NS3/4A protease
0.2 nM-3.5 nM


Solubility (25°C)* In vitro DMSO 144 mg/mL (196.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol 144 mg/mL (196.76 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.93 mL 69.65 mL 139.3mL
0.5 mM 2.79 mL 13.93 mL 27.86 mL
1 mM 1.39 mL 6.96 mL 13.93 mL
5 mM 0.28 mL 1.39 mL 2.79 mL

*The above data is based on the productmolecular weight 717.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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