Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. By competitively binding to NEP, Thiorphan inhibits its activity, thereby preventing the degradation of neuropeptides such as substance P and neurokinin A. This compound is particularly relevant in neonatal brain injury research, as it can elevate levels of these neuropeptides, activate NK1 and NK2 receptors, and mitigate excessive NMDA receptor activation, thus providing neuroprotection against excitotoxicity. Additionally, Thiorphan may play a role in studying respiratory diseases through its potential to inhibit NEP-mediated bronchoconstriction.
Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. By competitively binding to NEP, Thiorphan inhibits its activity, thereby preventing the degradation of neuropeptides such as substance P and neurokinin A. This compound is particularly relevant in neonatal brain injury research, as it can elevate levels of these neuropeptides, activate NK1 and NK2 receptors, and mitigate excessive NMDA receptor activation, thus providing neuroprotection against excitotoxicity. Additionally, Thiorphan may play a role in studying respiratory diseases through its potential to inhibit NEP-mediated bronchoconstriction.
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