CGS25155 is a potent inhibitor of neutral endopeptidase 24.11 (NEP 24.11) with an IC50 of 3 nM. By inhibiting NEP, CGS25155 effectively slows the degradation of the cardiac hormone atrial natriuretic peptide (ANP), demonstrating antihypertensive effects in the DOCA-salt induced rat hypertension model. This compound is valuable for research in cardiovascular diseases and the study of peptide metabolism.
CGS25155 is a potent inhibitor of neutral endopeptidase 24.11 (NEP 24.11) with an IC50 of 3 nM. By inhibiting NEP, CGS25155 effectively slows the degradation of the cardiac hormone atrial natriuretic peptide (ANP), demonstrating antihypertensive effects in the DOCA-salt induced rat hypertension model. This compound is valuable for research in cardiovascular diseases and the study of peptide metabolism.
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