Fig. 1 · Structure
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ZM223 hydrochloride
Cat. No.
A76948
CAS
2438679-27-5
NEDD8 Activating Enzyme Inhibitor
ZM223 hydrochloride is a potent non-covalent inhibitor of the NEDD8 activating enzyme (NAE). This compound demonstrates significant anticancer activity, making it a valuable tool in cancer research. Its primary mechanism involves the disruption of NEDD8 conjugation processes, which can lead to altered protein stability and function, thereby influencing various cellular pathways. ZM223 hydrochloride is suitable for investigating the roles of NEDD8 modifications in tumor biology and therapeutic responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2438679-27-5 |
| Applications | NEDD8 Activating Enzyme Inhibitor |
| Formula | C23H18ClF3N4O2S2 |
| Molecular Weight | 538.99 |
| SMILES | O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC3=CC=C(NC(CSC4=CC=C(N)C=C4)=O)C=C3S2.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.