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Bicyclic UK18

Catalog No.: A77002
uPA Inhibitor
Bicyclic UK18 is a competitive inhibitor of human urokinase-type plasminogen activator (uPA), demonstrating a Ki value of 53 nM. This compound plays a significant role in modulating fibrinolytic activity, making it useful in research related to thrombolysis and cancer metastasis. Its selective inhibition of uPA allows for detailed investigations into tissue remodeling and inflammatory processes.
Bicyclic UK18 1393680-45-9 uPA Inhibitor
Grouped product items
Size Price Stock Qty
1mg
$135.00
In stock
5mg
$350.00
In stock
10mg
$570.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBicyclic UK18 is a competitive inhibitor of human urokinase-type plasminogen activator (uPA), demonstrating a Ki value of 53 nM. This compound plays a significant role in modulating fibrinolytic activity, making it useful in research related to thrombolysis and cancer metastasis. Its selective inhibition of uPA allows for detailed investigations into tissue remodeling and inflammatory processes.
Product Information
Catalog NumA77002
FormulaC77H118N26O25S3
Molecular Weight1904.12
CAS Number1393680-45-9
SequenceAla-Cys-Ser-Arg-Tyr-Glu-Val-Asp-Cys-Arg-Gly-Arg-Gly-Ser-Ala-Cys-Gly (cyclized via TBMB and Cys2,9,16)
Sequence shorteningACSRYEVDCRGRGSACG (cyclized via TBMB and Cys2,9,16)
SMILESC([C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@]2(C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](C(NCC(O)=O)=O)CSCC3=CC(CSC[C@H](NC([C@H](C)N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)=CC(CSC2)=C3)[H])C4=CC=C(O)C=C4
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Proteases > Urokinase