Catalog No.
Product Name
Application
Product Information
Citations
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PREP Inhibitor
Pramiracetam sulfate is a selective inhibitor of prolyl endopeptidase (PREP). It has been shown to enhance cognitive function, particularly following traumatic brain injury, making it a valuable tool in studying neurodegenerative diseases. This compound is suitable for research focused on the mechanisms of cognitive enhancement and potential therapeutic interventions for brain injuries and related disorders. -
POP Inhibitor
POP-IN-2 is a potent, covalent inhibitor of prolyl oligopeptidase (POP) with a Ki value of 6 nM. This reagent serves as a valuable tool for investigating the physiological roles of POP in neurodegenerative diseases and cancer, facilitating research into therapeutic strategies targeting these conditions. Its high specificity makes it suitable for detailed mechanistic studies in various biological contexts. -
Gamma-Secretase Modulator
γ-Secretase modulator 13 is a gamma-secretase modulator that inhibits the production of the aggregated amyloid β-peptide Aβ42, exhibiting an IC50 value of 163 nM. This compound is valuable for research in Alzheimer's disease, facilitating investigations into amyloidogenic processes and potential therapeutic interventions. Its specific modulation of γ-secretase activity positions it as a significant tool for studying the mechanisms underlying neurodegenerative disorders. -
Serine Protease
Proteinase K is a nonspecific serine protease that effectively digests a wide variety of proteins. It exhibits robust activity in the presence of SDS or urea and functions across a broad pH range (4-12), temperature, and ionic conditions. This enzyme is commonly utilized in the extraction and detection of viral nucleic acids, making it a valuable tool in molecular biology and diagnostic applications. -
14-3-3 Protein-Protein Interaction Inhibitor
(E)-FOBISIN101 is a selective inhibitor of 14-3-3 protein-protein interactions, demonstrating IC50 values of 9.3 μM and 16.4 μM for the disruption of 14-3-3ζ and 14-3-3γ binding to PRAS40, respectively. This compound also inhibits 14-3-3's interactions with Raf-1 and proline-rich AKT substrates, and it neutralizes the activating effect of 14-3-3 on exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is valuable for research into 14-3-3-mediated pathways in cancer biology. -
Plasminogen Activator
Alteplase is a recombinant tissue plasminogen activator that acts primarily as a thrombolytic agent by converting plasminogen to plasmin, which leads to fibrinolysis. This compound is crucial in the management of acute ischemic stroke, pulmonary embolism, and acute myocardial infarction. Alteplase is also utilized for the treatment of occluded catheters, facilitating the restoration of vascular patency in clinical settings. -
VRK1 Inhibitor
VRK-IN-1 is a selective inhibitor of vaccinia-related kinase 1 (VRK1), with an IC50 value of 150 nM. This compound modulates the activity of human Ser/Thr protein kinases that are implicated in enhanced cell division and various neurological disorders. Its application in research may provide insights into cellular proliferation and potential therapeutic approaches for neurological conditions. -
uPA Inhibitor
UK122 TFA is a potent and selective inhibitor of urokinase-type plasminogen activator (uPA), exhibiting an IC50 of 0.2 μM. This compound demonstrates negligible inhibition of tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin, with IC50 values exceeding 100 μM. As a 4-oxazolidinone analogue, UK122 TFA acts as an anticancer agent, effectively inhibiting cancer cell migration and invasion, making it a valuable tool in cancer research. -
WNK1 Inhibitor
WNK1-IN-1 is a selective inhibitor of WNK1, exhibiting an IC50 of 1.6 μM. It effectively inhibits the phosphorylation of OSR1 with an IC50 of 4.3 μM. This compound is relevant for studies focused on blood pressure regulation and various aspects of cancer research, making it a valuable tool for elucidating the role of WNK1 in pathophysiological processes. -
KIAA1363/AADACL1 Inhibitor
JW480 is a selective inhibitor of KIAA1363/AADACL1 that displays potent oral bioactivity, with IC50 values of 12 nM against human KIAA1363 and 20 nM against mouse KIAA1363. Its mechanism involves inhibition of lipid deacetylase activity, which suppresses HAG metabolism and reduces retinyl ester hydrolase function in hepatic stellate cells. JW480 has demonstrated significant effects in reducing MAGE lipid levels and inhibiting critical processes such as migration, invasion, and tumor growth in prostate cancer cells. Additionally, it impacts platelet function and thrombosis, making it a valuable reagent for research in prostate cancer and thrombotic disorders. -
Serine Protease
Recombinant enterokinase (rEK) is a serine protease that functions as the physiological activator of trypsinogen, converting it into its active form, trypsin. This enzyme is essential for various biochemical assays and applications involving protein digestion and processing. Recombinant enterokinase is widely used in research focused on proteolytic processes, enzyme activation, and protein purification techniques. -
ASS1 Enzyme ctivators
LM2I is an argininosuccinate synthase (ASS1) enzyme activator derived from Spinosyn A. This compound demonstrates significant antiproliferative activity against various colorectal cancer cell lines and xenograft tumors. LM2I effectively inhibits colorectal cancer cell growth through the EGFR signaling pathway, making it a valuable tool for research in cancer biology and therapeutic development targeting ASS1. -
Protease Inhibitor
Benzamidine is a competitive protease inhibitor targeting enzymes such as plasmin, trypsin, and thrombin, effectively preventing the hydrolytic cleavage of glucagon. It is primarily employed to stabilize glucagon in human plasma and blood samples during collection, storage, and analysis, thereby ensuring accurate detection outcomes in research applications. While Benzamidine can induce slight single-strand DNA breaks at elevated concentrations, it demonstrates minimal overall genotoxicity. Additionally, it may interfere with certain glucagon antisera, although it does not significantly impact the affinity of key antigen-antibody interactions at specific concentrations. -
CITK Inhibitor
C3TD879 is a potent CITK inhibitor that targets the catalytic activity of CITK with an IC50 of 12 nM. It demonstrates a strong binding affinity for full-length human CITK in cellular assays, with a NanoBRET Kd of less than 10 nM. This compound serves as a valuable chemical probe for exploring the intricate biological functions associated with CITK, making it an essential tool for research in cell signaling and cancer biology. -
Trypsin Inhibitor
SFTI-1 is a cyclic peptide that functions as a potent trypsin inhibitor, comprising 14 amino acid residues. This compound is categorized within the Bowman-Birk class of inhibitors, notable for its remarkable stability and efficacy. SFTI-1 is a valuable tool for investigating peptide drug design and can significantly enhance research related to protease activity modulation. -
PKR Inhibitor
PKR-IN-C51 is an ATP-competitive inhibitor of the double-stranded RNA-activated protein kinase (PKR), demonstrating an IC50 of 9 μM. This compound effectively inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages. PKR-IN-C51 is valuable for research into PKR-mediated signaling pathways and therapeutic strategies targeting inflammatory responses. -
Serine Proteases Inhibitor
Benzamidine hydrochloride hydrate is a reversible competitive inhibitor of serine proteases, specifically targeting trypsin-like enzymes. It exhibits inhibitory constants (Kis) of 20 μM for Tryptase, 21 μM for Trypsin, 97 μM for uPA, 110 μM for Factor Xa, 320 μM for Thrombin, and 750 μM for tPA. This compound is widely utilized in biochemical research to study proteolytic processes and enzyme activity related to various physiological and pathological conditions. -
Trypsin Inhibitor
Camostat is an orally active inhibitor of trypsin, functioning by modulating proteolytic activity in various biological systems. This compound has demonstrated the ability to reduce pancreatic fibrosis in experimental models, specifically by inhibiting the proliferation and activation of pancreatic stellate cells (PSCs). Camostat serves as a valuable tool in research investigating pancreatic diseases and fibrosis-related mechanisms. -
Matriptase Inhibitor
Matriptase-IN-2 is a selective inhibitor of matriptase, a serine protease implicated in cartilage matrix degradation associated with osteoarthritis. With a Ki value of 5 nM, this secondary amide compound effectively inhibits matriptase activity, thereby preventing cartilage degradation. Matriptase-IN-2 is designed for research applications focused on understanding the role of matriptase in osteoarthritis pathology and potential therapeutic strategies. -
Plasminogen Activator
Tenecteplase is a genetically modified tissue plasminogen activator, designed to enhance thrombolytic efficacy. By introducing mutations in three specific gene loci, Tenecteplase facilitates the conversion of plasminogen to plasmin, promoting fibrinolysis. This reagent is primarily employed in research applications related to acute ischemic stroke, enabling investigations into treatment strategies and mechanisms of thrombus resolution. -
Serine/Threonine Kinase Inhibitor
Tilpisertib is a selective serine/threonine kinase inhibitor that targets key signaling pathways involved in cellular proliferation and survival. It has demonstrated significant antitumor activity, making it a valuable tool for cancer research and drug development. This compound is particularly useful for studying mechanisms of resistance in cancer therapies and evaluating the therapeutic potential of kinase inhibition in various tumor models. -
Serine Protease
Recombinant Kex2 protease is a membrane-bound, calcium-dependent serine protease that selectively cleaves carboxyl-terminal peptide bonds at dibasic amino acids. This enzyme plays a critical role in protein processing and maturation within cells. It is widely utilized in biological research for studying proteolytic pathways and for applications involving protein engineering and purification strategies. -
proteinase K inhibitor
MeOSuc-AAPF-CMK is a potent inhibitor of proteinase K, acting through the binding of its active site. This compound is primarily utilized in biochemical research to study protein degradation and enzyme inhibition mechanisms. Its effectiveness in blocking proteinase K activity makes it a valuable tool for investigating proteolytic pathways and cellular processes involving protein turnover. -
Hepsin Inhibitor
Hepln-13 is a selective Hepsin inhibitor, demonstrating an IC50 of 0.33 μM. Its potency and oral bioavailability make it a valuable tool for investigating the role of Hepsin in metastatic prostate cancer. Researchers can employ Hepln-13 to explore therapeutic strategies targeting Hepsin-mediated pathways in cancer progression. -
Plasmin Substrate
Boc-Val-Leu-Lys-AMC is a sensitive fluorogenic substrate specifically designed for the enzyme plasmin. This compound also serves as a substrate for acrosin derived from the ascidian Halocynthia roretzi, as well as porcine calpain isozymes I and II, and papain. Its distinct properties make it an invaluable tool for studying proteolytic activity and enzyme kinetics in various biological research applications. -
TNIK Inhibitor
TNIK-IN-1 is a potent inhibitor of Traf2 and Nck-interacting kinase (TNIK), exhibiting an IC50 of 65 nM. This compound demonstrates significant antitumor activity and is valuable for research investigating the role of TNIK in cancer progression and proliferation. Applications include studying TNIK-mediated signaling pathways and exploring its potential as a therapeutic target in oncology. -
Sperm Acrosin Inhibitor
4-Nitrophenyl 4-guanidinobenzoate hydrochloride is a potent inhibitor of sperm acrosin, a serine protease involved in fertilization. Its mechanism of action facilitates the inhibition of acrosin activity, crucial for sperm-egg fusion. Additionally, this compound acts as a substrate for trypsin, making it valuable for biochemical studies in protease activity and regulation. Researchers can utilize it in studies focused on reproductive biology and enzyme kinetics. -
Mast Cell Tryptase Inhibitor
APC 366 is a selective inhibitor of mast cell tryptase, exhibiting a Ki of 7.1 μM. This compound effectively inhibits antigen-induced early and late asthmatic responses, as well as bronchial hyperresponsiveness in sheep models of allergic asthma. APC 366 serves as a valuable tool for research in asthma pathophysiology and the development of therapeutic strategies targeting mast cell activity. -
TNIK Inhibitor
TNIK-IN-7 is a selective inhibitor of Traf2 and Nck-interacting kinase (TNIK), exhibiting an IC50 of 11 nM. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. Its specificity for TNIK allows for the exploration of signaling pathways involved in tumor progression and offers potential insights into targeted therapies for various cancers. -
Serine/threonine Kinase Inhibitor
Tilpisertib fosmecarbil TFA is the trifluoroacetic acid salt form of Tilpisertib, a potent inhibitor of serine/threonine kinases. This compound exhibits significant anti-inflammatory activity, making it valuable for research applications focused on inflammatory pathways and related diseases. Its mechanism of action allows for detailed exploration of kinase-related signal transduction processes in cellular models. -
Chymotrypsin Aα Substrate
Suc-AAPA-pNA is a synthetic peptide substrate specifically designed for the enzyme chymotrypsin Aα. This reagent is employed to evaluate the enzymatic activity of chymotrypsin Aα, providing insights into proteolytic processes involved in various biological functions. Its utility extends to research applications focused on enzyme kinetics and inhibitor studies. -
γ-Tryptase Substrate
D-Leu-Thr-Arg-pNA is a specific substrate for γ-Tryptase, enabling the quantitative assessment of γ-Tryptase activity in biochemical assays. This compound is valuable for studying the inhibition effects of small molecule inhibitors on γ-Tryptase, facilitating research in areas such as allergic responses and inflammation. Its application in enzyme activity assays makes it essential for exploring therapeutic interventions related to protease-mediated diseases. -
Ultraviolet Absorber
4,4'-Dihydroxybenzophenone is a phenolic ultraviolet absorber that primarily targets UV radiation, functioning as a protective agent in various applications. This compound serves as a crucial intermediate in the synthesis of several anticancer agents, including Sivifene. It has been shown to bind to the active site of trypsin, resulting in structural abnormalities and potential impacts on digestive function with prolonged exposure. Additionally, 4,4'-dihydroxybenzophenone exhibits low toxicity to Chlorella vulgaris and moderate toxicity to Daphnia magna, indicating its relevance in ecotoxicological studies. -
Protease Inhibitor
Patamostat is a potent protease inhibitor targeting trypsin, plasmin, and thrombin, with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively. This compound has demonstrated potential in suppressing the pathogenesis and development of acute pancreatitis. Its efficacy in inhibiting critical proteolytic enzymes makes Patamostat a valuable tool for research into protease-related disorders and therapeutic interventions. -
Matriptase Inhibitor
Matriptase-IN-2 free base is a potent matriptase inhibitor, exhibiting a Ki of 5 nM. This compound has significant potential for research applications focused on disorders of the musculoskeletal system. It provides a valuable tool for investigating the role of matriptase in various biological processes and therapeutic interventions. -
TNIK Inhibitor
PF-794 is a selective and potent inhibitor of Traf2- and Nck-interacting kinase (TNIK), exhibiting an IC50 of 39 nM. This ATP-competitive compound specifically targets the TNIK family, leading to a reduction in endogenous p120-catenin phosphorylation in cellular models. PF-794 is utilized in research related to psychiatric disorders, providing a valuable tool for studying the underlying mechanisms of these conditions. -
TAO Kinase Inhibitor
TAO Kinase Inhibitor 2 targets TAO Kinase and exhibits inhibitory activity with an IC50 range of 50 to 500 nM. Additionally, this compound inhibits KIAA1361 and JIK within the same IC50 range. Its selectivity and potency make it a valuable tool for studying the role of TAO Kinase and its related pathways in various biological contexts and disease models. -
Chymotrypsin Inactive Precursor
Chymotrypsinogen is the inactive precursor of the serine protease chymotrypsin, synthesized in the pancreas. Upon activation, it plays a crucial role in protein digestion by hydrolyzing peptide bonds. This reagent is important for biochemical studies involving protease activation and enzymatic activity, as well as for investigating digestive processes in vitro. -
Protease Inhibitor
[Des-Pro2]-Bradykinin is a potent protease inhibitor that effectively prevents the degradation of methionine enkephalin. By inhibiting proteolytic enzymes, it enhances the stability and activity of enkephalins, which are important neuropeptides involved in pain modulation and stress response. This reagent is valuable for studies focused on neurobiology, pain research, and peptide pharmacology. -
Landmark
STn/sialyl-Tn is a sialic acid glycan primarily associated with breast cancer, particularly in HER2-positive tumors. Its expression serves as a valuable biomarker for the identification and quantification of malignant cells in pathological nipple discharge (PND). This reagent is instrumental in cancer research and diagnostics, aiding in the assessment of tumor progression and treatment response. -
HGF-activating Serine Proteases Inhibitor
VD2173 is a macrocyclic peptide inhibitor specifically targeting HGF-activating serine proteases, including matriptase and hepsin. Demonstrating potent inhibition, VD2173 serves as a valuable tool for investigating the role of these proteases in various biological processes. Its use in research on lung cancer can elucidate mechanisms of tumor progression and potential therapeutic interventions. -
Serine/Threonine Kinase Inhibitor
Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases, demonstrating significant anti-inflammatory activity. This compound is valuable for research focused on inflammatory pathways and related signaling mechanisms. Its application may extend to studies investigating various diseases associated with dysregulated kinase activity. -
WNK Inhibitors
STOCK2S-26016 is a selective inhibitor of the WNK (With No K) signaling pathway, targeting WNK4 and WNK1 with IC50 values of 16 μM and 34.4 μM, respectively. This compound exhibits potential biological activity in the modulation of blood pressure regulation and hypertension-related research applications. Its specificity for WNK kinases makes it a valuable tool for studying the physiological and pathological roles of WNK signaling in various cellular processes. -
Tryptase Inhibitor
CRA-2059 is a highly selective tryptase inhibitor with a Ki of 620 pM for recombinant human tryptase-β (rHTβ). This compound demonstrates potent inhibition of tryptase activity, making it a valuable tool for research focused on allergic responses and tissue remodeling. Its specificity for tryptase positions CRA-2059 as an important reagent in studies of inflammatory diseases and related therapeutic development. -
Tripeptidyl-peptidase II Substrate
AAA-pNA is a chromogenic substrate specifically designed for the enzyme Tripeptidyl-peptidase II. This compound enables the quantification of Tripeptidyl-peptidase II activity through colorimetric analysis, facilitating studies on enzyme kinetics and functionality. It is useful in various research applications, including investigations into proteolytic processes and the role of Tripeptidyl-peptidase II in biological systems. -
TMPRSS6 Inhibitor
TMPRSS6-IN-1 is a potent inhibitor of TMPRSS6 (Matriptase-2), a type II transmembrane serine protease (TTSP). Inhibition of TMPRSS6 has been shown to alleviate symptoms associated with conditions such as hemochromatosis and beta thalassemia in preclinical models. This compound is valuable for studies targeting iron metabolism and therapeutic strategies aimed at managing related disorders. -
HtrA Serine Protease Inhibitor
JO146 is a selective inhibitor of the Chlamydia trachomatis high-temperature requirement A (CtHtrA) serine protease, exhibiting IC50 values of 21.86 μM for CtHtrA and 1.15 μM for human neutrophil elastase (HNE). This compound effectively inhibits the proteolytic activity associated with bacterial infections, making it a valuable tool for research into Chlamydia pathogenesis and potential therapeutic interventions. Its ability to target HtrA highlights its relevance in studies focused on bacterial virulence factors and protease biology. -
Urokinase Substrate
Z-Val-Gly-Arg-pNA is a chromogenic substrate specifically designed for the activity assessment of urokinase. Upon cleavage by urokinase, this substrate releases a p-nitroaniline (pNA) product, allowing for the quantification of urokinase activity through spectrophotometric measurement. This reagent is ideal for applications in studies of fibrinolysis, tissue remodeling, and related pathways where urokinase plays a crucial role. -
Protease Inhibitor
(Rac)-Telmesteine is a protease inhibitor that functions as an enzyme stabilizer. This compound is utilized in various applications, including enhancing the stability of proteases in detergents and cleaning agents. Its role as an enzyme stabilizer makes it applicable in research focused on enzyme activity and formulation development in the detergent industry. -
Fluorogenic Substrate
Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate specifically designed for the serine proteases factor XIIa and trypsin. Upon cleavage of the amide bond between arginine and the methylcoumarin amide moiety, it releases the fluorescent compound 7-Amino-4-methylcoumarin, enabling sensitive detection. This substrate is instrumental in studying proteolytic activity and can be utilized in various biochemical assays to monitor enzyme function.
