SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP). This compound enhances the biological activity of atrial natriuretic peptide (ANP) by preventing its hydrolysis, which is crucial for regulating blood pressure. Inhibition studies demonstrate that SCH-42354 exhibits IC50 values of 8.3 nM for leu-enkephalin and 10.0 nM for atrial natriuretic factor (ANF). Its significant antihypertensive activity makes it a valuable tool for cardiovascular research and the study of peptide regulation in clinical applications.
SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP). This compound enhances the biological activity of atrial natriuretic peptide (ANP) by preventing its hydrolysis, which is crucial for regulating blood pressure. Inhibition studies demonstrate that SCH-42354 exhibits IC50 values of 8.3 nM for leu-enkephalin and 10.0 nM for atrial natriuretic factor (ANF). Its significant antihypertensive activity makes it a valuable tool for cardiovascular research and the study of peptide regulation in clinical applications.
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