CRBN ligand-232

Catalog No.: A81259
Ligand for E3 Ligase
CRBN ligand-232 is a ligand for the E3 ubiquitin ligase cerberlon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to produce a PROTAC, enabling targeted protein degradation. Its application is particularly relevant in studies focusing on protein modulation and therapeutic intervention in various disease models.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
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Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionCRBN ligand-232 is a ligand for the E3 ubiquitin ligase cerberlon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to produce a PROTAC, enabling targeted protein degradation. Its application is particularly relevant in studies focusing on protein modulation and therapeutic intervention in various disease models.
Product Information
Catalog NumA81259
FormulaC17H15BrFNO3
Molecular Weight380.21
CAS Number3026676-91-2
SMILESO=C1C=2C(F)=CC(Br)=CC2CN1CC3=CC=C(OC)C=C3OC
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