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CRBN ligand-475

Ligand for E3 Ligase

CRBN ligand-475 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target-specific ligands through a linker to create proteolysis-targeting chimeras (PROTACs). CRBN ligand-475 is valuable for investigating targeted protein degradation and enhancing understanding of cellular mechanisms involved in disease pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925101-89-7
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₁N₃O₄
Molecular Weight	285.26
SMILES	O=C(O)C=1C=CC(=C2C=CC=NC12)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.