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CRBN ligand-485

Ligand for E3 Ligase

CRBN ligand-485 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound is utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands through a linker. Its primary application lies in targeted protein degradation research, enabling the modulation of specific protein levels in cellular systems for therapeutic investigations.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925097-49-8
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₄N₄O₂
Molecular Weight	258.28
SMILES	O=C1NC(=O)CCN1C=2C=C(N)C=C3C2C=CN3C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.