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CRBN ligand-584

Ligand for E3 Ligase

CRBN ligand-584 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), which enables the selective degradation of specific proteins of interest. It serves as a valuable tool in chemical biology for the study of protein function and the development of innovative therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925085-73-8
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₃N₅O₂
Molecular Weight	259.27
SMILES	O=C1NC(=O)CCN1C2=CC=C(N)C3=C2C=NN3C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.