(R,R,S)-AHPC

Catalog No.: A81260
Ligand for E3 Ligase
(R,R,S)-AHPC is a ligand for the E3 ligase von Hippel-Lindau (VHL). This compound is designed to recruit the VHL protein, facilitating the degradation of target proteins through the formation of PROTACs (Proteolysis Targeting Chimeras). By linking (R,R,S)-AHPC to specific target protein ligands, researchers can effectively study protein regulation and explore novel therapeutic strategies in cellular pathways.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(R,R,S)-AHPC is a ligand for the E3 ligase von Hippel-Lindau (VHL). This compound is designed to recruit the VHL protein, facilitating the degradation of target proteins through the formation of PROTACs (Proteolysis Targeting Chimeras). By linking (R,R,S)-AHPC to specific target protein ligands, researchers can effectively study protein regulation and explore novel therapeutic strategies in cellular pathways.
Product Information
Catalog NumA81260
FormulaC22H31ClN4O3S
Molecular Weight467.02
CAS Number2764746-08-7
SMILESCC1=C(SC=N1)C(C=C2)=CC=C2CNC([C@@H]3N(C[C@@H](C3)O)C([C@@H](N)C(C)(C)C)=O)=O.Cl
Synonyms(R,R,S)-VH032-NH2; (R,R,S)-VHL ligand 1
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