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CRBN ligand-322

Ligand for E3 Ligase

CRBN ligand-322 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to conjugate with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimeras). It is valuable for studying protein degradation pathways and exploring targeted protein degradation strategies in chemical biology and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925075-72-3
Applications	Ligand for E3 Ligase
Formula	C₁₂H₉BrN₄O₂
Molecular Weight	321.13
SMILES	O=C1NC(=O)CCN1C=2C=C(Br)C=C3N=CN=CC32

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.