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CRBN ligand-184

E3 Ubiquitin Ligases Ligand

CRBN ligand-184 is a selective ligand for CRBN-type E3 ubiquitin ligases. This compound plays a crucial role in the development of proteolysis-targeting chimeras (PROTACs), including the synthesis of PROTAC AU-24118. Its ability to engage E3 ligases provides valuable tools for targeted protein degradation research and the investigation of cellular protein dynamics.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2259851-81-3
Applications	E3 Ubiquitin Ligases Ligand
Formula	C₁₁H₁₁NO₃
Molecular Weight	205.21
SMILES	O=C(NC1=O)CCC1OC2=CC=CC=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.