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CRBN ligand-63

Ligands for E3 Ligase

CRBN ligand-63 is a ligand for the CRBN-type E3 ubiquitin ligase, functioning as a key component in the development of PROTAC (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by harnessing the cellular ubiquitin-proteasome system, offering valuable utility in research focused on protein regulation and therapeutic interventions. Its application extends to the study of cellular pathways and the modulation of protein levels in various biological contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3049446-57-0
Applications	Ligands for E3 Ligase
Formula	C₁₂H₁₂BrNO₃
Molecular Weight	298.13
SMILES	O=C(CCC1C2=CC(Br)=CC=C2OC)NC1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.