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CRBN ligand-221

Ligand for E3 Ligase

CRBN ligand-221 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in protein degradation pathways. This compound can be conjugated to a target protein ligand through a linker, allowing for the development of proteolysis targeting chimeras (PROTACs). Its applications include targeted protein degradation studies and the exploration of novel therapeutic strategies in various diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2412058-81-0
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₃N₃O₃
Molecular Weight	259.27
SMILES	O=C1NC(=O)C(N2C(=O)CC=3C(N)=CC=CC32)CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.