Fig. 1 · Structure
Documents & Downloads
CRBN ligand-707
Ligand for E3 Ligase
CRBN ligand-707 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively utilized to create proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its applications are vital in research related to targeted protein degradation and the modulation of cellular pathways governed by ubiquitin-proteasome system.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2925095-42-5 |
| Applications | Ligand for E3 Ligase |
| Formula | C11H9BrN4O3 |
| Molecular Weight | 325.12 |
| SMILES | O=C1NC(=O)C(N2N=C3C=CC=C(Br)N3C2=O)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.