Documents & Downloads

3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione

Ligands for E3 Ligase

3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione is a ligand for the CRBN-type E3 ubiquitin ligase, enabling the development of PROTAC (proteolysis-targeting chimeras) for targeted protein degradation. This compound facilitates the recruitment of ubiquitin ligases to specific proteins, highlighting its utility in studies focused on protein regulation and degradation pathways. Its application in drug discovery aims to enhance therapeutic strategies by modulating the cellular levels of target proteins.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2990057-63-9
Applications	Ligands for E3 Ligase
Formula	C₁₁H₉BrClNO₂
Molecular Weight	302.55
SMILES	O=C(C(C1=CC(Br)=CC=C1Cl)CC2)NC2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.